1372610-46-2

Basic information

• Product Name: 3-[N-benzyl((R)-1-cyclohexylethyl)amino]-(R)-propane-1,2-diol
• Synonyms: 3-[N-benzyl((R)-1-cyclohexylethyl)amino]-(R)-propane-1,2-diol
• CAS NO: 1372610-46-2
• Molecular Weight: 291.434
• Mol File: 1372610-46-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-[N-benzyl((R)-1-cyclohexylethyl)amino]-(R)-propane-1,2-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[N-benzyl((R)-1-cyclohexylethyl)amino]-(R)-propane-1,2-diol(1372610-46-2)
• EPA Substance Registry System: 3-[N-benzyl((R)-1-cyclohexylethyl)amino]-(R)-propane-1,2-diol(1372610-46-2)

Safety Data

• Hazardous Substances Data: 1372610-46-2(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 41122-67-2 (R) N-benzylidene-1-cyclohexylethylamine 
• 63167-00-0 (R)-N-benzyl-1-cyclohexylethylamine 
• 60456-23-7 (S)-oxiranemethanol 
• 5913-13-3 [(1R)-1-cyclohexylethyl]amine 

Relevant articles and documents

Asymmetric organocatalytic efficiency of synthesized chiral β-amino alcohols in ring-opening of glycidol with phenols

A series of novel chiral β-amino alcohols 3-5 and 7-10 were synthesized by regioselective ring opening of epoxides and chiral amines with a straightforward method in high yields (up to 99 %). Kinetic resolution of racemic glycidol with phenols was achieved by using chiral amino alcohols as organocatalysts. Amino alcohols 5, 8 and 10 exhibited the highest enantioselectivities with p-cresol, phenol, and p-methoxyphenol by 63, 65, 58 % ee, respectively. The moderate enantioselectivities were observed with catalyst 9b towards all the nucleophiles (34-48 % ee). The ee values of the desired 3-aryloxy-1, 2-diols were determined by HPLC. This study presents an attractive tool for the synthesis of β-blockers and structurally complex molecules.