137268-63-4Relevant articles and documents
Highly Stereoselective Asymmetric Hydrogenation of 2-Benzamidomethyl-3-oxobutanoate catalysed by Cationic binap-Ruthenium(II) Complexes
Mashima, Kazushi,Matsumura, Yoh-ichi,Kusano, Koh-hei,Kumobayashi, Hidenori,Sayo, Noboru,et al.
, p. 609 - 610 (2007/10/02)
Highly diastereoselective hydrogenation of methyl 2-benzamidomethyl-3-oxobutanoate has been accomplished by using (p-cymene)>I and corresponding complexes of derivatives of binap as catalyst, giving methyl (2S,3R)-2-benzamidomethyl-3-hydroxybutanoate, a versatile intermediate for the synthesis of β-lactam antibiotics, in up to 98percent diastereoisomeric excess and 99percent enantiomeric excess.