1373348-82-3Relevant articles and documents
An expeditious construction of 3-aryl-5-(substituted methyl)-2- oxazolidinones: A short and efficient synthesis of Linezolid
Tammana, Rajesh,Vemula, Kiran Kumar,Guruvindapalli, Ramadasu,Yanamandr, Ramesh,Gutta, Madhusudhan
, p. 45 - 56 (2012/03/11)
A short, concise and efficient synthesis of Linezolid was accomplished through a convergent scheme utilizing either (S)-1-azido-3-chloropropan-2-yl chloroformate or (S)-1- phthalimido-3- chloropropan-2-yl chloroformate as a key starting material. The synthesis demonstrates utility of (S)-1-azido-3- chloropropan-2-yl chloroformate and/or (S)-1-phthalimido-3-chloropropan-2-yl chloroformate to facilitate the expeditious construction of 3-aryl-5- (substituted methyl)-2- oxazolidinones and offers the possibility of accessing related 2-oxazolidinone members easily as well as making additional analogues of Linezolid. ARKAT-USA, Inc.