1373942-84-7Relevant articles and documents
Chiral Squaramide-Catalyzed Enantioselective Decarboxylative Addition of β-Keto Acids to Isatin Imines
Kaur, Jasneet,Kumari, Anita,Bhardwaj, Vimal K.,Chimni, Swapandeep Singh
, p. 1725 - 1734 (2017)
An efficient chiral squaramide-catalyzed enantioselective decarboxylative addition reaction of β-keto acids to isatin imines has been developed. The reaction proceeds smoothly using 20 mol% of organocatalyst to afford the chiral 3-aminooxindoles in high yield and excellent enantioselectivities. (Figure presented.).
Organocatalytic enantioselective peroxidation of ketimines derived from isatins
Nakamura, Shuichi,Takahashi, Shun
, p. 2590 - 2593 (2015)
The first catalytic enantioselective addition of hydroperoxides to ketimines derived from isatins has been developed. Excellent yields and enantioselectivities were observed for the reaction of various ketimines with peroxides using a cinchona alkaloid su
An enantioselective aza-Friedel-Crafts reaction of 5-aminoisoxazoles with isatin-derived: N -Boc ketimines
Liu, Hui,Yan, Yingkun,Li, Min,Zhang, Xiaomei
supporting information, p. 3820 - 3824 (2021/05/14)
By employing a chiral phosphoric acid as a catalyst, an enantioselective aza-Friedel-Crafts reaction of 5-aminoisoxazoles with isatin-derived N-Boc ketimines was realized. The reaction provided a wide variety of novel 3-isoxazole 3-amino-oxindoles with good yields (up to 99%) and moderate to good enantioselectivities (up to 99%). The absolute configuration of one product was assigned by X-ray crystal structural analysis and a plausible reaction mechanism was proposed. In addition, a scale-up reaction was performed successfully. Finally, one product was subjected to Suzuki-Miyaura coupling with phenylboronic acid to afford the product in a moderate yield without erosion of the enantioselectivity. This journal is
