1373957-61-9

Basic information

• Product Name: (R)-4-chloro-3-((E)-4-(4-fluorophenyl)-2-oxobut-3-enyl)-3-hydroxyindolin-2-one
• Synonyms: (R)-4-chloro-3-((E)-4-(4-fluorophenyl)-2-oxobut-3-enyl)-3-hydroxyindolin-2-one
• CAS NO: 1373957-61-9
• Molecular Weight: 345.758
• Mol File: 1373957-61-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-4-chloro-3-((E)-4-(4-fluorophenyl)-2-oxobut-3-enyl)-3-hydroxyindolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-chloro-3-((E)-4-(4-fluorophenyl)-2-oxobut-3-enyl)-3-hydroxyindolin-2-one(1373957-61-9)
• EPA Substance Registry System: (R)-4-chloro-3-((E)-4-(4-fluorophenyl)-2-oxobut-3-enyl)-3-hydroxyindolin-2-one(1373957-61-9)

Safety Data

• Hazardous Substances Data: 1373957-61-9(Hazardous Substances Data)

Upstream product

• 65300-29-0 (E)-4-(4-fluorophenyl)but-3-en-2-one 
• 6344-05-4 4-chloroisatin 

Relevant articles and documents

Asymmetric cross aldol addition of isatins with α,β-unsaturated ketones catalyzed by a bifunctional Br?nsted acid-Br?nsted base organocatalyst

The asymmetric cross-aldol reaction of isatins with α,β- unsaturated ketones has been developed under catalysis by a Cinchona alkaloid-derivated bifunctional Br?nsted acid-Br?nsted base catalyst, affording the aldol adducts in moderate to good yields (18-98%) with moderate to good enantioselectivities (30-97%). The noncovalent organo-catalyzed asymmetric cross-aldol reaction displays a broad substrate scope and wide functional-group tolerability, albeit the electronic and steric properties of both reaction partners have considerable and regular effects on the reactivity and stereocontrol.