1374035-93-4

Basic information

• Product Name: (R)-2-(benzhydrylamino)-3-phenylpropanenitrile
• Synonyms: (R)-2-(benzhydrylamino)-3-phenylpropanenitrile
• CAS NO: 1374035-93-4
• Molecular Weight: 312.414
• Mol File: 1374035-93-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-2-(benzhydrylamino)-3-phenylpropanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(benzhydrylamino)-3-phenylpropanenitrile(1374035-93-4)
• EPA Substance Registry System: (R)-2-(benzhydrylamino)-3-phenylpropanenitrile(1374035-93-4)

Safety Data

• Hazardous Substances Data: 1374035-93-4(Hazardous Substances Data)

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 80993-22-2 benzylmethylidenediphenylmethylamine 
• 623-49-4 ethyl cyanoformate 

Downstream Products

• 673-06-3 D-(R)-phenylalanine 
• 1374035-95-6 C₂₇H₃₂N₂O₂ 

Relevant articles and documents

Oxazoline-based organocatalyst for enantioselective strecker reactions: A protocol for the synthesis of levamisole

A chiral oxazoline-based or-ganocatalyst has been found to efficiently catalyze asymmetric Strecker reactions of various aromatic and aliphatic N-benzhydrylimines with trime-thylsilyl cyanide (TMSCN) as a cyanide source at -20°C to give α-aminoni-triles in high yield (96%) with excellent chiral induction (up to 98% ee). DFT calculations have been performed to rationalize the enantioselective formation of the product with the organo-catalyst in these reactions. The organo-catalyst has been characterized by single-crystal X-ray diffraction analysis, as well as by other analytical methods. This protocol has been extended to the synthesis of the pharmaceutically important drug molecule levamisole in high yield and with high enantioselectivity.