137420-59-8

Basic information

• Product Name: 2-(2-methoxycarbonyl-phenyl)-2-bromo-acetic acid methyl ester
• Synonyms: 2-(2-methoxycarbonyl-phenyl)-2-bromo-acetic acid methyl ester
• CAS NO: 137420-59-8
• Molecular Weight: 287.11
• Mol File: 137420-59-8.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 2-(2-methoxycarbonyl-phenyl)-2-bromo-acetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-methoxycarbonyl-phenyl)-2-bromo-acetic acid methyl ester(137420-59-8)
• EPA Substance Registry System: 2-(2-methoxycarbonyl-phenyl)-2-bromo-acetic acid methyl ester(137420-59-8)

Safety Data

• Hazardous Substances Data: 137420-59-8(Hazardous Substances Data)

Upstream product

• 89-51-0 Homophthalic acid 
• 716-43-8 dimethyl homophthalate 

Downstream Products

• 85974-70-5 methyl ortho-[(methoxycarbonyl)carbonyl]benzoate 
• 1620833-30-8 2-(6-benzyloxybenzo[d]thiazol-2-yl)-5H-isochromeno[3,4-d]thiazol-5-one 
• 1198278-74-8 methyl 2-cyano-2-(2-methoxycarbonylphenyl)acetate 

Relevant articles and documents

HCV PROTEASE INHIBITORS

The present invention discloses a compound of general formula (I); A is O, S, CH, NH or NR', when O links with Z3, Z1 is N or CRZ1, Z2 is CRZ2, when Z1 links with O, Z2 is CH, Z3 is C-Ar; Ra, Rb, Rc and Rd independently is H, OH, halogen or -Y1-Rm; A1 is NH or CH2; R1' is alkyl, aryl, cycloalkyl, heterocycloalkyl or heteroaryl; A2 is N, O or linking bond; R1 is hydrogen, or, R1 linking covalently with R3 forms C5-C9 saturated or unsaturated hydrocarbon chain substituted by O or N; R3 is alkyl, cycloalkyl, heterocycloalkyl, alkyl substituted by cycloalky etc; R4 is alkoxy-CO, alkyl-NHCO, (alkyl)2NCO, or formyl substituted by aryl, cycloalkyl, heterocycloalkyl.

HCV Protease Inhibitors

A compound of general formula (I); A is O, S, CH, NH or NR′, when O links with Z3, Z1 is N or CRZ1, Z2 is CRZ2, when Z1 links with O, Z2 is CH, Z3 is C—Ar; Ra, Rb, Rc and Rd independently is H, OH, halogen or —Y1—Rm; A1 is NH or CH2; R1′ is alkyl, aryl, cycloalkyl, heterocycloalkyl or heteroaryl; A2 is N, O or linking bond; R1 is hydrogen, or, R1 linking covalently with R3 forms C5-C9 saturated or unsaturated hydrocarbon chain substituted by O or N; R3 is alkyl, cycloalkyl, heterocycloalkyl, alkyl substituted by cycloalkyl etc; R4 is alkoxy-CO, alkyl-NHCO, (alkyl)2NCO, or formyl substituted by aryl, cycloalkyl, heterocycloalkyl.

An expedient synthesis of poly-substituted 1-arylisoquinolines from δ-ketonitriles via indium-mediated Barbier reaction protocol

We developed an efficient synthetic strategy of poly-substituted 1-arylisoquinolines via an indium-mediated Barbier type allylation from δ-ketonitriles. Initial attack of allylindium species occurred at the nitrile group selectively to form the enamine intermediate, which reacted with the ketone group intramolecularly to furnish the isoquinolines.