1374334-32-3Relevant articles and documents
Structure-Based Drug Design of Bisubstrate Inhibitors of Phenylethanolamine N-Methyltransferase Possessing Low Nanomolar Affinity at Both Substrate Binding Domains1
Lu, Jian,Bart, Aaron G.,Wu, Qian,Criscione, Kevin R.,McLeish, Michael J.,Scott, Emily E.,Grunewald, Gary L.
, p. 13878 - 13898 (2020)
The enzyme phenylethanolamine N-methyltransferase (PNMT, EC 2.1.1.28) catalyzes the final step in the biosynthesis of epinephrine and is a potential drug target, primarily for the control of hypertension. Unfortunately, many potent PNMT inhibitors also po