13745-26-1

Basic information

• Product Name: (1-(2-hydroxy-4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-2-propen-1-one)
• Synonyms: (1-(2-hydroxy-4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-2-propen-1-one)
• CAS NO: 13745-26-1
• Molecular Formula: C₁₉H₂₀O₆
• Molecular Weight: 344.3585
• Mol File: 13745-26-1.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (1-(2-hydroxy-4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-2-propen-1-one)(CAS DataBase Reference)
• NIST Chemistry Reference: (1-(2-hydroxy-4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-2-propen-1-one)(13745-26-1)
• EPA Substance Registry System: (1-(2-hydroxy-4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-2-propen-1-one)(13745-26-1)

Safety Data

• Hazardous Substances Data: 13745-26-1(Hazardous Substances Data)

Usage

Description

(1-(2-hydroxy-4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-2-propen-1-one), also known as Hesperetin, is a flavonoid compound found in citrus fruits and other plants. It is characterized by its antioxidant, anti-inflammatory, and anticancer properties. Its molecular structure consists of a hydroxyphenyl and trimethoxyphenyl group attached to a propenone backbone, making it a promising compound for drug development and natural health supplements.

Uses

Used in Pharmaceutical Industry:
(1-(2-hydroxy-4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-2-propen-1-one) is used as a therapeutic agent for various health conditions due to its antioxidant, anti-inflammatory, and anticancer properties. It has been studied for its potential therapeutic effects on diabetes, cardiovascular disease, and neurodegenerative disorders.
Used in Natural Health Supplements:
(1-(2-hydroxy-4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-2-propen-1-one) is used as a natural health supplement to promote overall health and well-being. Its antioxidant properties help protect the body from oxidative stress and support the immune system, while its anti-inflammatory properties may help reduce inflammation and support joint health.
Used in Drug Development:
(1-(2-hydroxy-4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-2-propen-1-one) is used as a compound for drug development due to its promising therapeutic effects and potential applications in treating various health conditions. Its unique molecular structure allows for further research and development into new pharmaceutical formulations and treatments.

Upstream product

• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 1262675-76-2 (E)‐1‐(2,4‐dimethoxyphenyl)‐3‐(3,4,5‐trimethoxyphenyl)prop‐2‐en‐1‐one 

Downstream Products

• 1119306-84-1 C₂₅H₂₇N₃O₇S 
• 19056-76-9 3,7,3',4',5'-O-pentamethylrobinetin 
• 138469-47-3 7,3',4',5'-tetramethoxyflavanone 
• 100211-06-1 baptigenin trimethyl ether 
• 490-31-3 robinetin 

Relevant articles and documents

Design and characterization of highly in vitro antitumor active ternary copper(II) complexes containing 2′-hydroxychalcone ligands

A series of innovative copper(II) complexes of the general composition [Cu(Ln)(phen)]NO3 (1–8; phen?=?1,10-phenanthroline), involving 2′-hydroxychalcone {(E)-1-(2′-hydroxyphenyl)-3-phenylprop-2-en-1-one} derivatives (HLn)

Novel insights into the mode of action of vasorelaxant synthetic polyoxygenated chalcones

Polyphenols consumption has been associated with a lower risk of cardiovascular diseases (CVDs) notably through nitric oxide (NO)- and estrogen receptor α (ERα)-dependent pathways. Among polyphenolic compounds, chalcones have been suggested to prevent end

In Vitro and in Vivo Antischistosomal Activities of Chalcones

In this study, we evaluated the in vitro and in vivo schistosomicidal activities of chalcones against Schistosoma mansoni worms. In vitro assays revealed that chalcones 1 and 3 were the most active compounds, without affecting significantly mammalian cells. Confocal laser scanning microscopy and scanning electron microscopy studies revealed reduction on the numbers of tubercles and morphological alterations in the tegument of S. mansoni worms after in vitro incubation with chalcones 1 and 3. In a mouse model of schistosomiasis, the oral treatment (400 mg/kg) with chalcone 1 or 3 significantly caused a total worm burden reduction in mice. Chalcone 1 showed significant inhibition of the S. mansoni ATP diphosphohydrolase activity, which was corroborated by molecular docking studies. The results suggested that chalcones could be explored as lead compounds with antischistosomal properties.