1374585-40-6

Basic information

• Product Name: C₃₂H₂₃F₃N₆O₂
• CAS NO: 1374585-40-6
• Molecular Weight: 580.569
• Mol File: 1374585-40-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₂H₂₃F₃N₆O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₂H₂₃F₃N₆O₂(1374585-40-6)
• EPA Substance Registry System: C₃₂H₂₃F₃N₆O₂(1374585-40-6)

Safety Data

• Hazardous Substances Data: 1374585-40-6(Hazardous Substances Data)

Upstream product

• 6980-11-6 7-chloro-3H-imidazo<4,5-b>pyridine 
• 273-21-2 3H-imidazo[4,5-b]pyridine 
• 1230788-51-8 N-(1-(3-nitrophenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl)benzamide 
• 1230788-50-7 4-amino-1-(3-nitrophenyl)-1H-pyrrolo[3,2-c]pyridine hydrochloride 
• 641571-13-3 3-(4-methyl-imidazol-1-yl)-5-trifluoromethylbenzoic acid 
• 1230788-53-0 N-(1-(3-aminophenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl)benzamide 

Relevant articles and documents

Design, synthesis, and antiproliferative activity of new 1H-pyrrolo[3,2-c]pyridine derivatives against melanoma cell lines. Part 2

A new series of diarylureas and diarylamides possessing 1H-pyrrolo[3,2-c]pyridine scaffold was designed and synthesized. Their in vitro antiproliferative activities against A375P human melanoma cell line and NCI-9 human melanoma cell line panel were tested. All the target compounds, except three amino derivatives 8g, h and 9h, demonstrated superior potencies against A375P to Sorafenib. In addition, compounds 8a and 9b-f demonstrated higher potencies than Vemurafenib against A375P. Compounds 8c and 9b were 7.50 and 454.90 times, respectively, more selective towards A375P melanoma cells over NIH3T3 fibroblasts. Furthermore, compounds 8d, e and 9a-d, f demonstrated very high potencies against the nine tested melanoma cell lines at the NCI. The bisamide derivatives 9a-c, f showed 2-digit nanomolar IC50 values over different cell lines of the NCI-9 melanoma cell lines.