137470-14-5

Basic information

• Product Name: N-(2-Chloro-quinolin-3-yl)-acetamide
• CAS NO: 137470-14-5
• Molecular Weight: 220.658
• Mol File: 137470-14-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(2-Chloro-quinolin-3-yl)-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Chloro-quinolin-3-yl)-acetamide(137470-14-5)
• EPA Substance Registry System: N-(2-Chloro-quinolin-3-yl)-acetamide(137470-14-5)

Safety Data

• Hazardous Substances Data: 137470-14-5(Hazardous Substances Data)

Upstream product

• 77800-16-9 3-acetamido-quinoline N-oxide 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 125917-60-4 2-chloro-3-(hydroxymethyl)quinoline 
• 35740-82-0 2-chloro-3-(bromomethyl)quinoline 
• 73568-25-9 2-chloro-3-quinoline carboxaldehyde 

Relevant articles and documents

REACTIONS OF 3-SUBSTITUTED QUINOLINE 1-OXIDES WITH ACYLATING AGENTS

Reactions of 3-fluoro- (1a), 3-bromo- (1b), 3-methyl- (1c), 3-methoxy- (1d) and 3-acetamidoquinoline 1-oxides (1e) with acylating agents (POCl3, Ac2O, TsCl and PhCOCl) were examined (Table).While only 2-substituted quinolines were obtained from 1a and 1b, fair amounts of 4-substituted products were formed in reactions of 1d, the sole formation of the 4-acetoxyquinoline (6) with Ac2O being the most significant result. 2-Chloroquinolines, 4-chloroquinolines and 2-tosyloxyquinolines were formed (and sometimes predominate) in addition to 2-quinolinones in reactions with TsCl.