1374966-98-9Relevant articles and documents
Reaction of (S)-homoserine lactone with Grignard reagents: synthesis of amino-keto-alcohols and β-amino acid derivatives
Gündo?du, ?zlem,Turhan, P?nar,K?se, Aytekin,Altunda?, Ramazan,Kara, Yunus
, p. 1163 - 1168 (2017/09/15)
The ring-opening reaction of homoserine lactone with phenylmagnesium bromides was systematically examined. A reliable method to achieve β-amino acid precursors was developed by tuning the reaction conditions to favor mono-addition to the carbonyl moiety of the lactone.
Manufacturing process for sitagliptin from L-aspartic acid
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Page/Page column 4-5, (2012/05/21)
The present invention relates to a novel manufacturing process of pharmaceutically active compound of formula I used as oral anti-diabetic drug. Starting from L-aspartic acid derivate of formula IV the invention describes preparation of the chiral (R)-β-amino acid of formula II known as a precursor in the synthesis of Sitagliptin (formula I).