1374968-15-6

Basic information

• Product Name: 3-(3-nitrophenyl)-6,7,8,9,10,11-hexahydro-1H-cycloocta[4,5]thieno[2,3-e]-1,4-diazepin-5-(4H)-one
• CAS NO: 1374968-15-6
• Molecular Weight: 369.444
• Mol File: 1374968-15-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(3-nitrophenyl)-6,7,8,9,10,11-hexahydro-1H-cycloocta[4,5]thieno[2,3-e]-1,4-diazepin-5-(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-nitrophenyl)-6,7,8,9,10,11-hexahydro-1H-cycloocta[4,5]thieno[2,3-e]-1,4-diazepin-5-(4H)-one(1374968-15-6)
• EPA Substance Registry System: 3-(3-nitrophenyl)-6,7,8,9,10,11-hexahydro-1H-cycloocta[4,5]thieno[2,3-e]-1,4-diazepin-5-(4H)-one(1374968-15-6)

Safety Data

• Hazardous Substances Data: 1374968-15-6(Hazardous Substances Data)

Upstream product

• 40106-15-8 2-amino-4,5,6,7,8,9-hexahydrocycloocta[4,5]thiophene-3-carboxamide 
• 2227-64-7 3'-nitro-2-bromoacetophenone 

Relevant articles and documents

Synthesis of thieno[2,3-d]pyrimidines, thieno[2,3-d]triazinones and thieno[2,3-e]diazepinones of anticipated anti-cancer activity

A novel series of 4-aminohexahydrocycloocta[4,5]thieno[2,3-d]pyrimidines, hexahydrocycloocta[4,5]thieno[2,3-d]-1,2,3-triazin-4-one and its N-3 substituted derivatives in addition to 3-aryl hexahydrocycloocta[4,5] thieno[2,3-e]-1,4- diazepin-5-ones were synthesised. Also, 2-(N-ethylcarbamothioylamino) hexahydrocycloocta[b] thiophene-3-carbonitrile and 19-imino tetradecahydrocycloocta[4',5'] thieno[2',3':4,5]pyrimido[1,6-a] cycloocta[4,5]thieno [3,2-e]pyrimidine-9-thione were prepared. Almost all the synthesised compounds exhibited anti-tumour activity against human colon carcinoma (HCT 116) cell line in vitro. Five compounds (IC50: 15.92, 22.59, 25.85, 27.40 and 29.70 μM, respectively) exhibited 2.16 to 1.15 fold more potent antitumour activity than imatinib (IC50: 34.40 μM).