13750-81-7Relevant articles and documents
Battlement-shaped 1D coordination polymer based on a bis(N-methylimidazole- 2-yl)butadiyne ligand
Waidmann, Thomas,Fritsch, Nico,Tucher, Johannes,Rudolf, Marc,Glaser, Felix,Guldi, Dirk M.,Burzlaff, Nicolai
, p. 10157 - 10160 (2013)
Bis(N-methylimidazole-2-yl)butadiyne (bmib) has been prepared starting from N-methylimidazole following two different pathways. Bmib fluoresces and is capable of forming 1D coordination polymers by clamping together metal units. The molecular structure of a zinc coordination polymer based on bmib and zinc acetate resembles a battlement of a fortress.
Structure-Activity Relationships for Reactivators of Organophosphorus-Inhibited Acetylcholinesterase: Quaternary Salts of 2-imidazole
Bedford, Clifford D.,Harris, Ralph N.,Howd, Robert A.,Miller, Alexi,Nolen, Harold W.,Kenley, Richard A.
, p. 1431 - 1438 (1984)
A series of 1,3-disubstituted-2-imidazolium halides were prepared and evaluated in vitro with respect to their ability to reactivate acetylcholinesterase inhibited by ethyl p-nitrophenyl methylphosphonate (EPMP) and 3,3-dimethyl-2-butyl methylphosphonofluoridate (GD).The compounds conform to the general formula +*Cl-, where R = CH3, (CH2)3CH3, (CH2)7CH3, CH2C6H5, CH2C10H7, (CH2)3C6H5, CH(CH3)2, CH2C(CH3)3, and CH(CH3)C(CH3)3.For comparison we also evaluated three known pyridinium reactivators, 2-PAM, HI-6, and toxogonin.The imidazolium aldoximes exhibit oxime acid dissociation constants (pKa) in the range 7.9-8.1, bracketing the value of 8.0, believed to be optimal for acetylcholinesterase reactivation.With imidazolium compound in excess over inhibited enzyme, the kinetics of reactivation are well behaved for EPMP-inhibited AChE and depend on the nature of the alkyl ether group R.For GD-inhibited AChE, maximal reactivation was used to compare compounds becouse rapid phosphonyl enzyme dealkylation and enzyme reihibition complicate interpretation of kinetic constants.
The synthesis of tripodal nitrogen donor ligands and their characterization as PdIIMe2 and PdIIIMe derivatives
Byers, Peter K.,Canty, Allan J.,Honeyman, Thomas
, p. 417 - 427 (1990)
New tripod ligands containing pyridin-2-yl (py), N-methylimidazol-2-yl (mim), and pyrazol-1-yl (pz) groups have been made by addition of 2-bromopyridine to deprotonated (py)(mim)CH2 or (mim)2CH2 to form (py)2(mim)CH and (py)(mim)2CH, or by simple condensation reactions of (pz)2CO with (mim)CHO or (py)CHO to form (pz)2(mim)CH and (pz)2(py)CH.The ligands may have general application in coordination and organometallic chemistry, especially bis(pyrazol-1-yl)(pyridin-2-yl)methane , which can be readily synthesized and is an unsymmetrical tripod closely relatedto (pz)3CH and (py)3CH.Dimethylpalladium(II) and methyl(iodo)palladium(II) complexes of the ligands have been isolated, and compared with complexes of (pz)3CH, (py)3CH and (pz)4C.
Tuning the optical properties of BODIPY dyes by N-rich heterocycle conjugation using a combined synthesis and computational approach
Banala, Srinivas,Kiessling, Fabian,Merkes, Jean Michel,Ostlender, Tobias,Sun, Haitao,Wang, Fufang
supporting information, p. 19641 - 19645 (2021/11/12)
The increased number of N-atoms induced a blueshift in absorption and a gain in fluorescence quantum yield, from 750 nm and ~0% for pyrrole to 635 nm and ~40% for triazole, respectively. DFT calculations indicated a decrease in HOMO energy levels with the
Multi-substituted amine compound and its preparation and use (by machine translation)
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Paragraph 0711; 0715-0717, (2018/04/27)
The invention belongs to the field of medical technology, in particular, the present invention provides the following formula I shown multi-substituted amine compound or its isomer or its pharmaceutically acceptable salt, ester, prodrug or hydrate, its pharmaceutical composition, preparation method thereof and its use in the preparation of medicine for treating aids in use. The compound or pharmaceutical composition containing the compound can be used as an inhibitor for inhibiting HIV integrase with LEDGF/p75 between protein - protein interaction and HIV integrase dimerization, then can be used for the treatment of aids. . (by machine translation)