137525-83-8Relevant articles and documents
Metabolic and chemical origins of cross-reactive immunological reactions to arylamine benzenesulfonamides: T-cell responses to hydroxylamine and nitroso derivatives
Castrejon, J. Luis,Lavergne, Sidonie N.,El-Sheikh, Ayman,Farrell, John,Maggs, James L.,Sabbani, Sunil,O'Neill, Paul M.,Kevin Park,Naisbitt, Dean J.
, p. 184 - 192 (2011/02/16)
Exposure to sulfamethoxazole (SMX) is associated with T-cell-mediated hypersensitivity reactions in human patients. T-cells can be stimulated by the putative metabolite nitroso SMX, which binds irreversibly to protein. The hydroxylamine and nitroso deriva
