1375701-67-9Relevant articles and documents
Discovery of macrocyclic peptides armed with a mechanism-based warhead: Isoform-selective inhibition of human deacetylase SIRT2
Morimoto, Jumpei,Hayashi, Yuuki,Suga, Hiroaki
supporting information; experimental part, p. 3423 - 3427 (2012/06/30)
Designed to inhibit: By using the random nonstandard peptide integrated discovery (RaPID) system, highly potent isoform-selective inhibitors can be identified from a library of nonstandard macrocyclic peptides (see picture). These inhibitors, which contain a mechanism-based warhead residue, are active against the human deacetylase SIRT2, with IC50 values in the low nanomolar region. Copyright