137593-52-3

Basic information

• Product Name: GR 64349
• Synonyms: GR 64349;LYS-ASP-SER-PHE-VAL-GLY-R-GAMMA-LACTAM-LEU-MET-NH2;[LYS3, GLY8-R-GAMMA-LACTAM-LEU9]NEUROKININ A (3-10);L-Lys-L-Asp-L-Ser-L-Phe-L-Val-N-[(3R)-1-[(R)-1-[[[(S)-1-(Aminocarbonyl)-3-(methylthio)propyl]amino]carbonyl]-3-methylbutyl]-2-oxo-3α-pyrrolidinyl]-NH2;L-Methioninamide,L-lysyl-L-a-aspartyl-L-seryl-L-phenylalanyl-L-valyl-(aS,3R)-3-amino-a-(2-methylpropyl)-2-oxo-1-pyrrolidineacetyl-
• CAS NO: 137593-52-3
• Molecular Formula: C₄₂H₆₈N₁₀O₁₁S
• Molecular Weight: 921.11
• Product Categories: AgonistPeptides for Cell Biology;Neuropeptides;Peptides for Cell Biology;Tachykinins
• Mol File: 137593-52-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 1342.8°Cat760mmHg
• Flash Point: 765.9°C
• Appearance: /
• Density: 1.31g/cm³
• Storage Temp.: −20°C
• PKA: 4.13±0.10(Predicted)
• CAS DataBase Reference: GR 64349(CAS DataBase Reference)
• NIST Chemistry Reference: GR 64349(137593-52-3)
• EPA Substance Registry System: GR 64349(137593-52-3)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 137593-52-3(Hazardous Substances Data)

Usage

Description

GR 64349 is a compound that acts as a potent and selective agonist at the NK-2 tachykinin receptor. It is known for initiating changes in various parts of the body, including the colon, intestine, and spinal cord.

Uses

Used in Pharmaceutical Industry:
GR 64349 is used as a pharmacological tool for studying the effects and functions of the NK-2 tachykinin receptor. Its agonist properties allow researchers to investigate the receptor's role in various physiological processes and potential therapeutic applications.
Used in Gastrointestinal Research:
In the field of gastrointestinal research, GR 64349 is used as a research compound to understand the role of the NK-2 tachykinin receptor in the colon and intestine. This helps in exploring its potential for developing treatments for gastrointestinal disorders and understanding the underlying mechanisms of these conditions.
Used in Neurological Research:
GR 64349 is also used as a research compound in the field of neurological research, particularly in studying the spinal cord. Its agonist activity at the NK-2 tachykinin receptor aids in understanding the receptor's involvement in pain transmission and other neurological functions, which could lead to the development of new treatments for neurological disorders.

Upstream product

• 86060-87-9 Fmoc-Val-OPfp 
• 86060-92-6 N-α-Fmoc-L-phenylalanine pentafluorophenyl ester 
• 71989-28-1 N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine 
• 143267-21-4 (R)-2-<3-<(tert-butoxycarbonyl)amino>-2-oxo-1-pyrrolidinyl>-(S)-4-methylpentanoic acid pentafluorophenyl ester 
• 124202-00-2 (R)-2-<3-<(tert-butoxycarbonyl)amino>-2-oxo-1-pyrrolidinyl>-(S)-4-methylpentanoic acid methyl ester 
• 82611-48-1 (2S)-2-<(3R)-3-<(tert-butoxycarbonyl)amino>-2-oxopyrrolidin-1-yl>-4-methylpentanoic acid 
• 82611-46-9 N-(tert-butoxycarbonyl)-D-methionyl-L-leucine methyl ester 

Relevant articles and documents

Conformationally Constrained Tachykinin Analogues: Potent and Highly Selective Neurokinin NK-2 Receptor Agonists

The design and synthesis of potent and selective neurokinin NK-2 receptor agonists 12 (GR64349) and 31 are described, together with structure-activity relationships for related analogues.Compound 12 (EC50 = 3.7 nM at NK-2 receptors in the rat colon; selectivity >1000- and >300-fold with respect to NK-1 and NK-3 receptors, respectively) was derived by incorporation of a Gly-Leu γ-lactam conformational constraint into the C-terminal region of the neurokinin A octapeptide analogue 3>-NKA(3-10).Compound 31 (EC50 = 15 nM in rat colon) contains a novel fused-bicyclicconstraint at the corresponding site in the substance P hexapeptide analogue 6>-SP(6-11).