137601-29-7

Basic information

• Product Name: 1-acetyl-5-(trifluoroacetyl)-1,2,3,5-tetrahydropyrrolo<2,3-f>indole
• Synonyms: 1-acetyl-5-(trifluoroacetyl)-1,2,3,5-tetrahydropyrrolo<2,3-f>indole
• CAS NO: 137601-29-7
• Molecular Weight: 296.249
• Mol File: 137601-29-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-acetyl-5-(trifluoroacetyl)-1,2,3,5-tetrahydropyrrolo<2,3-f>indole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-acetyl-5-(trifluoroacetyl)-1,2,3,5-tetrahydropyrrolo<2,3-f>indole(137601-29-7)
• EPA Substance Registry System: 1-acetyl-5-(trifluoroacetyl)-1,2,3,5-tetrahydropyrrolo<2,3-f>indole(137601-29-7)

Safety Data

• Hazardous Substances Data: 137601-29-7(Hazardous Substances Data)

Upstream product

• 4993-96-8 1-(5-aminoindolin-1-yl)ethanone 

Downstream Products

• 158942-04-2 5-methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2,3-f]indole 
• 7075-68-5 dihydrobenzo-<1,2-b:4,5-b'>-dipyrrole 

Relevant articles and documents

5-Methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrroloindole: A Novel 5-HT2C/5-HT2B Receptor Antagonist with Improved Affinity, Selectivity, and Oral Activity

The preparation of a series of conformationally restricted analogues of indolylurea 1, namely tetrahydropyrroloindoles and tetrahydropyrroloquinolines, is described.The binding affinities of these compounds at 5-HT2A, 5-HT2B, and 5-HT2C receptors were determined.Of these compounds, the 1,2,3,5-tetrahydropyrroloindole derivative, compound 11, was found to have high affinity for the 5-HT2C (pK1 8.0) and 5-HT2B receptors (pA2 8.5), with excellent selectivity over the 5-HT2A and various other receptors (pK1B 8.8), and an in vivo functional model, mCPP-induced hypolocomotion (ID50 5.5 mg/kg po). 11 should therefore be of significant utility as a pharmacological tool to delineate the functional significance of blockade of 5-HT2B and 5-HT2C receptors.