137618-52-1

Basic information

• Product Name: Butanenitrile, 3-hydroxy-4-(phenylmethoxy)-
• CAS NO: 137618-52-1
• Molecular Formula: C11H13NO2
• Molecular Weight: 191.23
• Mol File: 137618-52-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Butanenitrile, 3-hydroxy-4-(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanenitrile, 3-hydroxy-4-(phenylmethoxy)-(137618-52-1)
• EPA Substance Registry System: Butanenitrile, 3-hydroxy-4-(phenylmethoxy)-(137618-52-1)

Safety Data

• Hazardous Substances Data: 137618-52-1(Hazardous Substances Data)

Upstream product

• 2930-05-4 Benzyloxymethyl-oxiran 
• 143-33-9 sodium cyanide 
• 13071-59-5 3-benzyloxypropan-1,2-diol 
• 100-51-6 benzyl alcohol 
• 83527-35-9 S-3,4-dihydroxy butyronitrile 
• 620-05-3 iodomethylbenzene 
• 4704-76-1 4-(benzyloxymethyl)-1,3-dioxo-2-thiolane 2-oxide 

Downstream Products

• 173666-23-4 3-(benzyloxymethyl)acrylonitrile 
• 147849-64-7 tert-butyl (S)-6-(benzyloxy)-5-hydroxy-3-oxohexanoate 
• 366016-77-5 (3S)-4-(Benzyloxy)-3-(trimethylsilyloxy)butyronitrile 
• 366016-78-6 (S)-4-(benzyloxy)-3-hydroxybutanenitrile 
• 107400-44-2 ethyl 3-oxo-5-hydroxy-6-benzyloxyhexanoate 

Relevant articles and documents

MORPHOLINE AND 1,4-OXAZEPANE AMIDES AS SOMATOSTATIN RECEPTOR SUBTYPE 4 (SSTR4) AGONISTS

The invention relates to morpholine and 1,4-oxazepane amide derivatives of general formula (I), which are agonists of somatostatin receptor subtype 4 (SSTR4), useful for preventing or treating medical disorders related to SSTR4. In addition, the invention

Efficient lipase-catalyzed kinetic resolution of 4-arylmethoxy-3-hydroxybutanenitriles: application to an expedient synthesis of a statin intermediate

The kinetic resolution of 4-arylmethoxy-3-hydroxybutanenitriles was investigated by lipase-catalyzed transesterification in organic solvents. A high enantioselectivity was obtained via reaction with vinyl acetate in a mixed solvent (n-heptane/acetonitrile 1:1), which was catalyzed by the lipase from Artgribacter sp. A better selectivity was demonstrated when the number of substituents on the aryl ring increased. (S)-4-Arylmethoxy-3-hydroxybutanenitriles can be obtained with enantiomeric excesses of up to 98.0% by this method. Furthermore we have developed a novel route to synthesize tert-butyl (S)-6-benzyloxy-5-hydroxy-3-oxohexanoate, a key intermediate for the preparation of HMG-CoA reductase inhibitors (statins).

Nucleophilic Addition to Cyclic 1,2-Sulfites

Addition of heteroatom nucleophiles has been shown to attack at either the C5- or the S-atom sites in 4-(benzyloxymethyl)-1,3-dioxa-2-thiolane 2-oxide.No C4-reactivity was observed.The regioselectivity depended on the type of nucleophile.