1376615-57-4

Basic information

• Product Name: C₂₂H₁₈ClFN₂O₄
• CAS NO: 1376615-57-4
• Molecular Weight: 428.847
• Mol File: 1376615-57-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₁₈ClFN₂O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₁₈ClFN₂O₄(1376615-57-4)
• EPA Substance Registry System: C₂₂H₁₈ClFN₂O₄(1376615-57-4)

Safety Data

• Hazardous Substances Data: 1376615-57-4(Hazardous Substances Data)

Upstream product

• 773-91-1 5-fluoro-1-methylisatin 
• 118923-96-9 2-chloro-6-methylphenyl isocyanide 
• 623-47-2 propynoic acid ethyl ester 

Relevant articles and documents

Atom-economical synthesis of the functionalized spirocyclic oxindole-butenolide via three-component [2 + 2 + 1] cycloaddition strategy

The intermolecular [2 + 2 + 1] multicomponent cycloadditions from readily available isocyanides, activated alkynes and isatins are disclosed. This reaction proceeds by way of a Michael addition-nucleophilic addition- intramolecular cyclization sequence, thus providing new access to spirocyclic oxindole-butenolide with exclusive stereoselectivity in an efficient and atom-economical manner. A broad range of isatins and isocyanides including sterically demanding ones are also found to be compatible with the present protocol, which offers an opportunity for the construction of a new compound library. This protocol also allows the insertion of carbon monoxide into organic molecules without the aid of transition metal catalyst after hydrolysis process. Moreover, the cycloaddition-hydrolysis process by step can be further developed into a practical and powerful one-pot strategy in good yields together with convenient experimental set-up, which adds to its attractiveness.