1376676-65-1

Basic information

• Product Name: N,2,3-trimethyl-2H-indazole-6-amine
• Synonyms: N,2,3-trimethyl-2H-indazole-6-amine
• CAS NO: 1376676-65-1
• Molecular Weight: 175.233
• Mol File: 1376676-65-1.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: N,2,3-trimethyl-2H-indazole-6-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N,2,3-trimethyl-2H-indazole-6-amine(1376676-65-1)
• EPA Substance Registry System: N,2,3-trimethyl-2H-indazole-6-amine(1376676-65-1)

Safety Data

• Hazardous Substances Data: 1376676-65-1(Hazardous Substances Data)

Usage

General Description

N,2,3-trimethyl-2H-indazole-6-amine is a chemical compound with the molecular formula C10H14N2. It is a derivative of indazole, a heterocyclic aromatic organic compound. N,2,3-trimethyl-2H-indazole-6-amine is a yellowish crystalline powder that is soluble in organic solvents such as ethanol and ether. N,2,3-trimethyl-2H-indazole-6-amine has potential applications in pharmaceutical and chemical industries, being used as an intermediate in the synthesis of various drugs and other organic compounds. Its chemical properties and structure make it suitable for use in the development of new drugs and other chemical products.

Upstream product

• 1142189-49-8 6-bromo-2,3-dimethyl-1H-indazole 
• 74-89-5 methylamine 
• 90221-46-8 3-methyl-6-bromo-2H-indazole 
• 14922-91-9 2-ethyl-5-bromoaniline 
• 10342-66-2 4-bromo-1-ethyl-2-nitro-benzene 
• 593-51-1 methylamine hydrochloride 
• 612-22-6 2-nitro(ethylbenzene) 
• 67-56-1 methanol 
• 444731-72-0 2,3-dimethyl-6-amino-2H-indazole 
• 1313372-75-6 3?methyl?6?nitro?1H?indazole 
• 578-54-1 ortho-ethylaniline 
• 20191-74-6 2-ethyl-5-nitroaniline 
• 444731-73-1 2,3?dimethyl?6?nitro?2H?indazole 
• 6494-19-5 3-methyl-6-nitro-1H-indazole 

Downstream Products

• 635702-64-6 pazopanib hydrochloride 
• 444731-75-3 N-(2-chloropyrimidin-4-yl)-N-methyl-2,3-dimethyl-2H-indazole-6-amine 
• 444731-52-6 pazopanib 

Relevant articles and documents

A NOVEL PROCESS FOR PREPARATION OF PAZOPANIB HYDROCHLORIDE

The present invention relates to a new process for the preparation of a key intermediate compound and its use in a synthetic process for the preparation of pazopanib hydrochloride. The method has advantages of a simple operation, high yield and low costs. The present invention also relates to a novel polymorph of pazopanib hydrochloride.

MATERIALS AND METHODS FOR STRATIFYING AND TREATING CANCERS

The present invention relates to materials and methods for stratifying and treating cancers and to methods of identifying/selecting patients for treatment of cancer with tyrosine kinase inhibitors. Gene expression profiles, TP53 mutations and FGFR1 and PDGFRA expression are used to identify/select/stratify the cancers and patients.

Hydrochloric acid [...] of the method for the preparation of intermediates

The invention discloses a preparation method of an intermediate (2,3-dimethyl-N-(2-chloropyrimidine-4-base)-N-methyl-2H-indazole-6-amine) of pazopanib hydrochloride as shown in a formula I. The preparation method comprises the step of performing nucleophilic substitution reaction on a compound III and 2,4-dichloropyrimidine in an organic solvent under the action of alkali, wherein the reaction temperature is 0-160 DEG C. According to the preparation method disclosed by the invention, raw materials are low in price and easy to obtain, and the preparation method is convenient to operate, high in product yield and suitable for industrial large-scale production.