137813-35-5 Usage
Description
CYCLO(ARG-GLY-ASP-D-PHE-VAL), also known as a cyclic peptide, is a potent inhibitor of cell adhesion. It is composed of a series of amino acids, including arginine, glycine, aspartic acid, D-phenylalanine, and valine, which are arranged in a cyclic structure. This cyclic peptide has been found to have various biological activities, making it a promising candidate for pharmaceutical and medical applications.
Uses
Used in Pharmaceutical Industry:
CYCLO(ARG-GLY-ASP-D-PHE-VAL) is used as an inhibitor of tumor cell adhesion for preventing the attachment of cancer cells to extracellular matrix proteins such as laminin and vitronectin. This property makes it a potential therapeutic agent in the treatment of various types of cancer.
Used in Renal Medicine:
In the field of renal medicine, CYCLO(ARG-GLY-ASP-D-PHE-VAL) is used for the amelioration of ischemic acute renal failure in rats. Its ability to inhibit tubular obstruction by preventing cell-cell adhesion helps in the treatment and management of kidney-related conditions.
Used in Cellular Signaling Research:
CYCLO(ARG-GLY-ASP-D-PHE-VAL) is also used as a research tool to study the redistribution of c-Src into focal adhesions and its subsequent effects on MAP Kinase activation. This application aids in understanding the underlying mechanisms of cell adhesion and signaling pathways, which can be crucial for the development of new therapeutic strategies.
Biochem/physiol Actions
Primary Targetinhibits tumor cell adhesion to laminin and vitronectin substrates
Check Digit Verification of cas no
The CAS Registry Mumber 137813-35-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,7,8,1 and 3 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 137813-35:
(8*1)+(7*3)+(6*7)+(5*8)+(4*1)+(3*3)+(2*3)+(1*5)=135
135 % 10 = 5
So 137813-35-5 is a valid CAS Registry Number.
