1378390-29-4

Basic information

• Product Name: 3-(2-bromoacetyl)-10,11-dihydro-5H-Benzo[d]naphtho[2,3-b]pyran-8(9H)-one
• Synonyms: 3-(2-bromoacetyl)-10,11-dihydro-5H-Benzo[d]naphtho[2,3-b]pyran-8(9H)-one;3-(2-Bromo-acetyl)-10,11-dihydro-5H,9H-6-oxa-benzo[a]anthracen-8-one;3-(2-Bromoacetyl)-10,11-dihydro-5H-benzo[d]naphtho[2,3-b]pyran-8(9H)-one 3-(2-Bromoacetyl)-10,11-dihydro-5H-benzo[d]naphtho[2,3-b]pyran-8(9H)-one ;3-(2-Bromoacetyl)-10,11-dihydro-5h-dibenzo[c,g]chromen-8(9h)-on;Velpatasvir Intermediate 7
• CAS NO: 1378390-29-4
• Molecular Formula: C₁₉H₁₅BrO₃
• Molecular Weight: 371.2246
• EINECS: -0
• Mol File: 1378390-29-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 578.6±50.0 °C(Predicted)
• Appearance: /
• Density: 1.514±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3-(2-bromoacetyl)-10,11-dihydro-5H-Benzo[d]naphtho[2,3-b]pyran-8(9H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-bromoacetyl)-10,11-dihydro-5H-Benzo[d]naphtho[2,3-b]pyran-8(9H)-one(1378390-29-4)
• EPA Substance Registry System: 3-(2-bromoacetyl)-10,11-dihydro-5H-Benzo[d]naphtho[2,3-b]pyran-8(9H)-one(1378390-29-4)

Safety Data

• Hazardous Substances Data: 1378390-29-4(Hazardous Substances Data)

Usage

Description

3-(2-bromoacetyl)-10,11-dihydro-5H-Benzo[d]naphtho[2,3-b]pyran-8(9H)-one is a complex organic compound with a unique chemical structure. It is characterized by its antiviral properties and serves as an intermediate in the synthesis of Velpatasvir (V116000), a medication used to treat hepatitis C virus (HCV) infections.

Uses

Used in Pharmaceutical Industry:
3-(2-bromoacetyl)-10,11-dihydro-5H-Benzo[d]naphtho[2,3-b]pyran-8(9H)-one is used as an antiviral agent for the development of medications targeting hepatitis C virus (HCV) infections. Its role as an intermediate in the synthesis of Velpatasvir (V116000), a NS5A inhibitor, highlights its importance in the treatment of HCV.
Used in Antiviral Research:
3-(2-bromoacetyl)-10,11-dihydro-5H-Benzo[d]naphtho[2,3-b]pyran-8(9H)-one is also utilized in the field of antiviral research, where it contributes to the discovery and development of new antiviral drugs. Its unique chemical structure and antiviral properties make it a valuable asset in the ongoing fight against viral infections, particularly those caused by the hepatitis C virus.

Upstream product

• 1378391-36-6 3-vinyl-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one 
• 1378388-19-2 7-(2-bromo-5-chlorobenzyloxy)-3,4-dihydronaphthalene-1(2H)-one 
• 22009-38-7 7-hydroxy-1-tetralone 
• 66192-24-3 2-bromo-5-chlorobenzyl bromide 
• 1378388-20-5 3-chloro-10,11-dihydro-5H-benzo[d]naphtho[2,3-b]pyran-8(9H)-one 
• 1378391-38-8 3-(2-bromo-1-hydroxyethyl)-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one 

Downstream Products

• 1378390-35-2 (2S,5S)-2-(2-(9-bromo-8-oxo-8,9,10,11-tetrahydro-5H-dibenzo[c,g]chromen-3-yl)-2-oxoethyl) 1-tert-butyl 5-methylpyrrolidine-1,2-dicarboxylate 
• 1378390-69-2 (2S,4S)-2-(2-(9-bromo-8-oxo-8,9,10,11-tetrahydro-5H-dibenzo[c,g]chromen-3-yl)-2-oxoethyl) 1-tert-butyl 4-methylpyrrolidine-1,2-dicarboxylate 
• 1378391-42-4 (2S,4S)-2-(2-(9-bromo-8-oxo-8,9,10,11-tetrahydro-5H-dibenzo[c,g]chromen-3-yl)-2-oxoethyl) 1-tert-butyl 4-(methoxymethyl)pyrrolidine-1,2-dicarboxylate 
• 1378391-43-5 (2R,4R)-1-tert-butyl 2-(2-(9-((2S,5S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)-5-methylpyrrolidine-2-carbonyloxy)-8-oxo-8,9,10,11-tetrahydro-5H-dibenzo[c,g]chromen-3-yl)-2-oxoethyl) 4-(methoxymethyl)pyrrolidine-1,2-dicarboxylate 

Relevant articles and documents

PROCESSES FOR PREPARING ANTIVIRAL COMPOUNDS

The present disclosure provides processes for the preparation of a compound of formula: which is useful as an antiviral agent. The disclosure also provides compounds that are synthetic intermediates.

CONDENSED IMIDAZOLYLIMIDAZOLES AS ANTIVIRAL COMPOUNDS

The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.