137937-39-4

Basic information

• Product Name: Ethanone, 1-(2-hydroxy-6-methylphenyl)-2-phenyl-
• Synonyms: 1-(2-Hydroxy-6-methyl-phenyl)-2-phenyl-ethanone
• CAS NO: 137937-39-4
• Molecular Formula: C15H14O2
• Molecular Weight: 226.275
• Mol File: 137937-39-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 85°C
• CAS DataBase Reference: Ethanone, 1-(2-hydroxy-6-methylphenyl)-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(2-hydroxy-6-methylphenyl)-2-phenyl-(137937-39-4)
• EPA Substance Registry System: Ethanone, 1-(2-hydroxy-6-methylphenyl)-2-phenyl-(137937-39-4)

Safety Data

• Hazardous Substances Data: 137937-39-4(Hazardous Substances Data)

Usage

Preparation

Obtained (by-product) by Fries rearrangement of m-tolyl phenylacetate with aluminium chloride in chlorobenzene at 140° for 4 h (5%).

Upstream product

• 2491-29-4 2-methylphenyl phenylacetate 
• 1030446-72-0 2-methoxy-6-methylbenzaldehyde oxime 
• 1408089-50-8 1-(2-methoxy-6-methylphenyl)-2-phenylethanone 
• 53005-44-0 2-methoxy-6-methyl-benzonitrile 
• 54884-55-8 2-methoxy-6-methyl-benzaldehyde 
• 122-27-0 3-methylphenyl phenylacetate 

Downstream Products

• 1408089-52-0 2-(1-(benzyloxy)ethyl)-5-methyl-3-phenyl-4H-chromen-4-one 
• 1408089-54-2 2-(1-hydroxyethyl)-5-methyl-3-phenyl-4H-chromen-4-one 

Relevant articles and documents

NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES

The present invention provides PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.

Selectivity in the photo-Fries reaction of phenyl phenylacetates included in a nation membrane

Photoirradiation of phenyl phenylacetates included within a Nafion membrane exclusively resulted in ortho-hydroxyphenones, thus achieving high selectivity in the photo-Fries reaction.

A REEXAMINATION OF THE RETRO-FRIES REARRANGEMENT OF SOME o-HYDROXYKETONES

The retro-Fries rearrangement, catalyzed by protic and Lewis acids, was studied for some o-hydroxyketones.The results are consistent with the mechanism of an heterolytic cleavage and rearrangement.It appears that, in general, Lewis acids do not induce the retro-Fries rearrangement of o-hydroxyketones.However, in certain cases, it may be brought about the presence of a protic acid generated in situ, from a solvent-catalyst interaction.