1379445-88-1

Basic information

• Product Name: tert-Butyl (5-methyl-3-phenyl-1-quinolin-4-yl-1H-pyrazol-4-yl)acetate
• Synonyms: tert-Butyl (5-methyl-3-phenyl-1-quinolin-4-yl-1H-pyrazol-4-yl)acetate
• CAS NO: 1379445-88-1
• Molecular Weight: 399.492
• Mol File: 1379445-88-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: tert-Butyl (5-methyl-3-phenyl-1-quinolin-4-yl-1H-pyrazol-4-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl (5-methyl-3-phenyl-1-quinolin-4-yl-1H-pyrazol-4-yl)acetate(1379445-88-1)
• EPA Substance Registry System: tert-Butyl (5-methyl-3-phenyl-1-quinolin-4-yl-1H-pyrazol-4-yl)acetate(1379445-88-1)

Safety Data

• Hazardous Substances Data: 1379445-88-1(Hazardous Substances Data)

Upstream product

• 116423-03-1 tert-butyl 3-acetyl-4-oxopentanoate 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 15793-93-8 4-hydrazineylquinoline 
• 1379445-77-8 3-benzoyl-4-oxopentanoic acid tert-butyl ester 
• 93-91-4 1-phenylbutan-1,3-dione 
• 371764-64-6 quinolin‐4‐ylboronic acid 
• 1322082-29-0 tert-Butyl (5-methyl-3-phenyl-1H-pyrazol-4-yl)acetate 

Downstream Products

• 1379445-48-3 (5-methyl-3-phenyl-1-quinolin-4-yl-1H-pyrazol-4-yl)acetic acid 

Relevant articles and documents

2-(1H-Pyrazol-4-yl)acetic acids as CRTh2 antagonists

High throughput screening identified the pyrazole-4-acetic acid substructure as CRTh2 receptor antagonists. Optimisation of the compounds uncovered a tight SAR but also identified some low nanomolar inhibitors.

NEW PYRAZOLE DERIVATIVES HAVING CRTH2 ANTAGONISTIC BEHAVIOUR

The present invention relates to a compound of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by CRTh2 antagonist activity.