1379609-57-0

Basic information

• Product Name: dicyanomethyl N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamate
• Synonyms: dicyanomethyl N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamate
• CAS NO: 1379609-57-0
• Molecular Weight: 532.519
• Mol File: 1379609-57-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: dicyanomethyl N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamate(CAS DataBase Reference)
• NIST Chemistry Reference: dicyanomethyl N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamate(1379609-57-0)
• EPA Substance Registry System: dicyanomethyl N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamate(1379609-57-0)

Safety Data

• Hazardous Substances Data: 1379609-57-0(Hazardous Substances Data)

Upstream product

• 1379609-56-9 dicyanomethyl N-[4-(methylamino)benzoyl]-L-glutamic acid 
• 52853-40-4 6-bromomethyl-2,4-diaminopteridine hydrobromide 

Downstream Products

• 7413-34-5 disodium methotrexate 

Relevant articles and documents

A NEW METHOD FOR PRODUCING ANTIFOLATE AGENTS HAVING GLUTAMIC ACID PART IN THEIR STRUCTURE

A new method for producing antifolate agents having glutamic acid part in their structure is developed by protecting carboxyl groups of glutamic acid or its N-subsituted derivatives as cyanomethyl ester to give compounds of formula (II) which are hydrolyzed under very mild conditions to afford antifolate agents in high yield with high analytical and optical purity.