1379659-20-7Relevant articles and documents
A Direct approach to a 6-hetarylamino[1,2,4]triazolo[4,3-b][1,2,4,5] tetrazine library
Palysaeva, Nadezhda V.,Kumpan, Katerina P.,Struchkova, Marina I.,Dalinger, Igor L.,Kormanov, Aleksandr V.,Aleksandrova, Nataly S.,Chernyshev, Victor M.,Pyreu, Dmitrii F.,Suponitsky, Kyrill Yu.,Sheremetev, Aleksei B.
supporting information, p. 406 - 409 (2014/04/03)
The synthesis of 6-hetarylamino[1,2,4]triazolo[4,3-b]-[1,2,4,5]tetrazines is reported. The functionalized secondary amines were constructed via a K 2CO3-mediated SNAr reaction of weakly basic hetarylamines with 3-(3,5-dimethylpyrazol-1-yl)[1,2,4]triazolo[4,3-b]-[1,2,4,5]tetrazines, which allowed displacement 3,5-dimethylpyrazolyl leaving group. Significantly, the reaction exhibited a broad substrate scope and proceeded in good yields.
