1379768-21-4

Basic information

• Product Name: C₂₆H₃₀N₂O₈
• CAS NO: 1379768-21-4
• Molecular Weight: 498.533
• Mol File: 1379768-21-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₆H₃₀N₂O₈(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₆H₃₀N₂O₈(1379768-21-4)
• EPA Substance Registry System: C₂₆H₃₀N₂O₈(1379768-21-4)

Safety Data

• Hazardous Substances Data: 1379768-21-4(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 1379768-40-7 3-diazo-7-methoxy-1-methylindolin-2-one 
• 153463-32-2 (S)-4-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-1-(4-methoxyphenyl)azetidine-2,3-dione 
• 84575-27-9 7-methoxy-1H-indole-2,3-dione 
• 79223-90-8 7-methoxy-1-methyl-2,3-dihydro-1H-indole-2,3-dione 

Relevant articles and documents

Diastereoselective synthesis of β-Lactam-oxindole hybrids through a three-component reaction of azetidine-2,3-diones, α-diazo-oxindoles, and alcohols catalyzed by [Rh2(OAc)4]

β-Lactam-oxindole hybrids have been synthesized in good yields in a one-pot procedure through efficient and stereoselective capture of an oxonium ylide with azetidine-2,3-diones. The reaction allows high to moderate control of stereoselectivity, depending on the 3-diazo-oxindole precursor and the hydroxylic compound used. Two new quaternary stereogenic centers were formed; the stereochemistry at the C-3 quaternary center was controlled by a bulky substituent at C-4, whereas the stereoselectivity in the adjacent second quaternary stereogenic center was controlled by the α-diazo-oxindole. The stereochemistry of both quaternary centers has been unambiguously assigned by single-crystal X-ray diffraction. Densely functionalized β-lactam-oxindole hybrids have been prepared in a one-pot, multicomponent reaction between azetidine-2,3-diones, α-diazo-oxindoles, and alcohols. Two new stereogenic centers were formed; the stereochemistry at the new C-3 quaternary center was controlled by a bulky substituent at C-4, whereas the second new stereogenic center was controlled by the α-diazo-oxindole.