1379796-40-3

Basic information

• Product Name: N-benzyl 2-(hydroxyimino)-2-(isoquinolin-1-yl)acetamide
• Synonyms: N-benzyl 2-(hydroxyimino)-2-(isoquinolin-1-yl)acetamide
• CAS NO: 1379796-40-3
• Molecular Weight: 305.336
• Mol File: 1379796-40-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-benzyl 2-(hydroxyimino)-2-(isoquinolin-1-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl 2-(hydroxyimino)-2-(isoquinolin-1-yl)acetamide(1379796-40-3)
• EPA Substance Registry System: N-benzyl 2-(hydroxyimino)-2-(isoquinolin-1-yl)acetamide(1379796-40-3)

Safety Data

• Hazardous Substances Data: 1379796-40-3(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 1379796-37-8 N-benzyl 2-(isoquinolin-1-yl)acetamide 
• 855292-39-6 isoquinolineacetic acid 
• 69582-88-3 methyl 3-amino-2-(isoquinolin-1-yl)but-2-enoate 

Downstream Products

• 1379796-26-5 (RS)-N-benzyl 2-amino-2-(isoquinolin-1-yl)acetamide 

Relevant articles and documents

Synthesis, anticonvulsant activity, and neuropathic pain-attenuating activity of N-benzyl 2-amino-2-(hetero)aromatic acetamides

N-Benzyl 2-acetamido-2-substituted acetamides, where the 2-substituent is a (hetero)aromatic moiety, are potent anticonvulsants. We report the synthesis and whole animal pharmacological evaluation of 16 analogues where the terminal 2-acetyl group was removed to give the corresponding primary amino acid derivatives (PAADs). Conversion to the PAAD structure led to a substantial drop in seizure protection in animal tests, demonstrating the importance of the N-acetyl moiety for anticonvulsant activity. However, several of the PAADs displayed notable pain-attenuating activities in a mouse model.