138-15-8 Usage
Description
L-(+)-Glutamic acid hydrochloride, also known as L-glutamate hydrochloride, is a white crystalline powder that serves as a major excitatory neurotransmitter in the mammalian central nervous system (CNS). It is obtained through chemical synthesis and is soluble in water, with very slight solubility in alcohol and ether. L-glutamic acid hydrochloride interacts with membrane-bound glutamate receptors, playing a crucial role in various physiological processes.
Uses
1. Flavoring and Salt Substitute:
L-(+)-Glutamic acid hydrochloride is used as a flavor enhancer in the food industry, providing a savory taste known as umami. It is also utilized as a salt substitute, offering a similar taste to traditional salt without the associated health risks.
2. Digestive Aid:
In the pharmaceutical industry, L-(+)-Glutamic acid hydrochloride is employed as a digestive aid, helping to improve the absorption and utilization of nutrients in the body.
3. Cell Culture Component:
L-(+)-Glutamic acid hydrochloride is used in cell culture as a component of the MEM (Minimal Essential Medium) non-essential amino acids solution, which is essential for the growth and maintenance of various cell types.
4. Nitrogen Source in Fumagillin Production:
In the biotechnology industry, L-(+)-Glutamic acid hydrochloride has been used as a nitrogen source in the culture of Aspergillus fumigatus NRRL 2436 for the production of fumagillin, a compound with potential applications in agriculture and medicine.
Biochem/physiol Actions
L-glutamate plays key roles in development, learning, memory, plasticity and cognition. It plays crucial role in the pathogenesis of neuropathological diseases such as epilepsy, schizophrenia, stroke, ischemia, ALS (amyotrophic lateral sclerosis), Huntington′s disease and Parkinson′s disease. Glutamate is also responsible for the activation of long-term potentiation (LTP) and long-term depression (LTD). Induction of glutamate receptors plays a key role in the pathophysiology of migraine.
Check Digit Verification of cas no
The CAS Registry Mumber 138-15-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,3 and 8 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 138-15:
(5*1)+(4*3)+(3*8)+(2*1)+(1*5)=48
48 % 10 = 8
So 138-15-8 is a valid CAS Registry Number.
InChI:InChI=1/C5H9NO4.ClH/c6-3(5(9)10)1-2-4(7)8;/h3H,1-2,6H2,(H,7,8)(H,9,10);1H/t3-;/m0./s1
138-15-8Relevant articles and documents
LYSINE ISOTOPOLOGUES, COMPOSITIONS COMPRISING THE SAME AND METHODS OF SYNTHESIS
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Paragraph 0159-0162, (2016/02/12)
This invention relates to lysine isotopologues of Formulas I and 1-A, as described herein, and processes for synthesizing the same and derivatives and intermediates involved therein. In one aspect, described herein is a chemical compound comprising an isotopically labeled analog, i.e., an isotopologue of a standard or naturally occurring lysine. The lysine isotopologue is synthetically formed to have stable isotopes of elements incorporated at selected positions. As such, the lysine isotopologue has a molecular mass different from the mass of a standard or naturally occurring lysine.
Micropeptins from an Israeli fishpond water bloom of the cyanobacterium microcystis sp
Zafrir, Ella,Carmeli, Shmuel
experimental part, p. 352 - 358 (2010/08/05)
Seven new natural products, micropeptin MZ845 (1), micropeptin MZ859 (2), micropeptin MZ939A (3), micropeptin MZ925 (4), micropeptin MZ939B (5), micropeptin MZ1019 (6), and micropeptin MZ771 (7), as well as two known micropeptins, cyanopeptolin S (8) and cyanopeptolin SS (9), were isolated from the hydrophilic extract of the cyanobacterium Microcystis sp. that was collected from a fishpond in Kibbutz Ma'ayan Tzvi, Israel, in July 2006. The structures of the pure natural products were elucidated using spectroscopic methods, including UV, 1D and 2D NMR, and MS techniques. The absolute configuration of the chiral centers of the compounds was determined using Marfey's method for HPLC. The inhibitory activity of the compounds was determined for the serine proteases: trypsin, chymotrypsin, thrombin, and elastase. These micropeptins inhibited trypsin with IC50's that varied between 0.6 and 24.2 μM. The SAR of these micropeptins is discussed.
Highly enantioselective synthesis of cyclic and functionalized α-amino acids by means of a chiral phase transfer catalyst
Corey,Noe, Mark C,Xu, Feng
, p. 5347 - 5350 (2007/10/03)
The chiral quaternary ammonium salt 1 serves as phase transfer catalyst for the enantioselective conversion of the glycine derivative 2 to a variety of cyclic and acyclic chiral α amino acids with enantioselectivities as high as 200:1 in alkylation and Michael addition reactions.