1380095-73-7Relevant articles and documents
Total synthesis of exiguamines A and B inspired by catecholamine chemistry
Sofiyev, Vladimir,Lumb, Jean-Philip,Volgraf, Matthew,Trauner, Dirk
supporting information; experimental part, p. 4999 - 5005 (2012/06/04)
The evolution of a total synthesis of the exiguamines, two structurally unusual natural products that are highly active inhibitors of indolamine-2,3-dioxygenase (IDO), is described. The ultimately successful strategy involves advanced cross-coupling methodology and features a potentially biosynthetic tautomerization/electrocyclization cascade reaction that forms two heterocycles and installs a quaternary ammonium ion in a single synthetic operation. Copyright
