1380106-64-8

Basic information

• Product Name: 3-[2-chloro-4-(5-chloro-6-methoxy-pyridin-3-yl)-phenyl]-N-hydroxy-acrylamide hydrochloride
• Synonyms: 3-[2-chloro-4-(5-chloro-6-methoxy-pyridin-3-yl)-phenyl]-N-hydroxy-acrylamide hydrochloride
• CAS NO: 1380106-64-8
• Molecular Weight: 375.639
• Mol File: 1380106-64-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-[2-chloro-4-(5-chloro-6-methoxy-pyridin-3-yl)-phenyl]-N-hydroxy-acrylamide hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[2-chloro-4-(5-chloro-6-methoxy-pyridin-3-yl)-phenyl]-N-hydroxy-acrylamide hydrochloride(1380106-64-8)
• EPA Substance Registry System: 3-[2-chloro-4-(5-chloro-6-methoxy-pyridin-3-yl)-phenyl]-N-hydroxy-acrylamide hydrochloride(1380106-64-8)

Safety Data

• Hazardous Substances Data: 1380106-64-8(Hazardous Substances Data)

Upstream product

• 158435-41-7 4-bromo-2-chlorobenzaldehyde 
• 31928-47-9 4-bromo-2-chloroiodobenzene 
• 1380106-78-4 3-(4-bromo-2-chloro-phenyl)-acrylic acid methyl ester 
• 942438-89-3 (5-chloro-6-methoxypyridin-3-yl)boronic acid 
• 1380106-79-5 3-(4-bromo-2-chloro-phenyl)-N-(tetrahydropyran-2-yloxy)-acrylamide 

Relevant articles and documents

Reexamining hydroxamate inhibitors of botulinum neurotoxin serotype A: Extending towards the β-exosite

Botulinum neurotoxins (BoNTs) are the most toxic proteins known to man, exposure to which results in flaccid paralysis. Given their extreme potency, these proteins have become studied as possible weapons of bioterrorism; however, effective treatments that function after intoxication have not progressed to the clinic. Here, we have reexamined one of the most effective inhibitors, 2,4-dichlorocinnamyl hydroxamate, in the context of the known plasticity of the BoNT/A light chain metalloprotease. Our studies have shown that modifications of this compound are tolerated and result in improved inhibitors, with the best compound having an IC50 of 0.23 μM. Given the inconsistency of structure-activity relationship trends observed across similar compounds, this data argues for caution in extrapolating across structural series.