1380345-63-0Relevant articles and documents
Direct asymmetric reductive amination of α-keto acetals: A platform for synthesizing diverse α-functionalized amines
Chiu, Pauline,Shi, Yongjie,Wang, Chenhan,Wang, Jingxin,Yang, Feifan,Yin, Qin,Zhang, Xumu
supporting information, p. 513 - 516 (2022/01/22)
We report an efficient and straightforward method to synthesize enantio-enriched N-unprotected α-amino acetals via ruthenium-catalyzed direct asymmetric reductive amination. The α-amino acetal products are versatile and valuable platform molecules that can be converted to the corresponding α-amino acids, amino alcohols, and other derivatives by convenient transformations.
Synergistic Catalysis of Se and Cu for the Activation of α-H of Methyl Ketones with Molecular Oxygen/Alcohol to Produce α-Keto Acetals?
Chen, Chao,Cao, Zhicheng,Zhang, Xu,Li, Yiming,Yu, Lei,Jiang, Xuefeng
, p. 1045 - 1051 (2020/06/30)
Selenium and copper synergistically catalyzed the oxidation/alkoxylation of methyl ketones to synthesize α-keto acetals directly. Using O2 as oxidant and alcohol as solvent and alkoxylation reagent, the reaction is practical from industrial viewpoint. Mechanistic studies revealed that copper promoted the oxidation of organoselenium intermediates with O2 to allow the key rearrangement and selenoxide syn-elimination regenerating the catalytically active organoselenium species.
One-pot synthesis of α-ketoacetals from aryl methyl ketones in the presence of selenous acid catalyzed by boron trifluoride etherate
Kharkongor, Icydora,Myrboh, Bekington
, p. 4359 - 4362 (2015/06/22)
A simple and efficient one-pot preparation of α-ketoacetals from substituted acetophenones and triethylorthoformate in the presence of H2SeO3 and BF3·Et2O as catalyst has been developed. The desired products are obtained in good yields by a simple protocol involving neat and mild reaction conditions. The present methodology provides an attractive alternative method for the preparation of α-ketoacetal derivatives.
