1380587-87-0

Basic information

• Product Name: 1-[4'-(5-amino-1-methyl-1H-pyrazol-4-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester
• Synonyms: 1-[4'-(5-amino-1-methyl-1H-pyrazol-4-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester
• CAS NO: 1380587-87-0
• Molecular Weight: 361.444
• Mol File: 1380587-87-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-[4'-(5-amino-1-methyl-1H-pyrazol-4-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4'-(5-amino-1-methyl-1H-pyrazol-4-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester(1380587-87-0)
• EPA Substance Registry System: 1-[4'-(5-amino-1-methyl-1H-pyrazol-4-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester(1380587-87-0)

Safety Data

• Hazardous Substances Data: 1380587-87-0(Hazardous Substances Data)

Upstream product

• 1380587-40-5 1-[4'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1'-biphenyl]-4-yl]cyclopropane-1-carboxylic acid ethyl ester 
• 105675-85-2 4-bromo-2-methyl-2H-pyrazol-3-ylamine 
• 1215205-50-7 ethyl 1-(4-bromophenyl)cyclopropane-1-carboxylate 
• 71597-85-8 (p-hydroxyphenyl)boronic acid 

Downstream Products

• 1402466-24-3 methyl 1-(4'-(5-(benzyloxycarbonylamino)-1-methyl-1H-pyrazol-4-yl)biphenyl-4-yl)cyclopropanecarboxylate 
• 1402466-23-2 ethyl 1-(4'-(5-(benzyloxycarbonylamino)-1-methyl-1H-pyrazol-4-yl)biphenyl-4-yl)cyclopropanecarboxylate 
• 1396007-02-5 1-{4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester 
• 1402466-13-0 ethyl 1-(4'-(5-(((2-methoxy-1-phenylethoxy)carbonyl)amino)-1-methyl-1H-pyrazol-4-yl)-[1,1 '-biphenyl]-4-yl)cyclopropanecarboxylate 
• 1402466-17-4 (R)-ethyl 1-(4'-(1-methyl-5-((3-methylbutan-2-yloxy)carbonylamino)-1H-pyrazol-4-yl)biphenyl-4-yl)cyclopropanecarboxylate 
• 1396007-20-7 (R)-1-{4'-[5-(1,2-dimethylpropoxycarbonylamino)-1-methyl-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid 
• 1396007-17-2 (R)-1-{4'-[5-(sec-butoxycarbonylamino)-1-methyl-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid 
• 1396007-08-1 (R)-1-{4'-[5-((1-(2-fluorophenyl)ethoxy)carbonylamino)-1-methyl-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid 
• 1396007-14-9 (R)-1-{4'-[1-methyl-5-((1-(3-(trifluoromethyl)-phenyl)ethoxy)-carbonylamino)-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid 
• 1396007-11-6 1-{4'-[5-((1-(4-fluorophenyl)ethoxy)carbonylamino)-1-methyl-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid 
• 1396007-05-8 1-{4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid 
• 1402465-25-1 1-(4'-{5-[1-(2-chloro-phenyl)ethoxycarbonylamino]-1-methyl-1H-pyrazol-4-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid 

Relevant articles and documents

SUBSTITUTED PYRAZOLE COMPOUNDS AS LPAR ANTAGONISTS

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of inflammatory diseases and disorders such as, for example, pulmonary fibrosis

COMPOSITIONS AND METHODS FOR MODULATING LPA RECEPTORS

The present invention relates to compounds of Formula (1), or pharmaceutically acceptable salts thereof and their pharmaceutical compositions, wherein variables are as defined herein, which are useful as modulators of the activity of lysophosphatidic acid (LPA).