1380593-13-4

Basic information

• Product Name: (Z)-2-(3-hydroxy-4-nitrophenyl)-5-(4-methoxybenzylidene)-5H-thiazol-4-one
• Synonyms: (Z)-2-(3-hydroxy-4-nitrophenyl)-5-(4-methoxybenzylidene)-5H-thiazol-4-one
• CAS NO: 1380593-13-4
• Molecular Weight: 356.359
• Mol File: 1380593-13-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (Z)-2-(3-hydroxy-4-nitrophenyl)-5-(4-methoxybenzylidene)-5H-thiazol-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-2-(3-hydroxy-4-nitrophenyl)-5-(4-methoxybenzylidene)-5H-thiazol-4-one(1380593-13-4)
• EPA Substance Registry System: (Z)-2-(3-hydroxy-4-nitrophenyl)-5-(4-methoxybenzylidene)-5H-thiazol-4-one(1380593-13-4)

Safety Data

• Hazardous Substances Data: 1380593-13-4(Hazardous Substances Data)

Upstream product

• 18495-15-3 3-hydroxy-4-nitrobenzonitrile 
• 123-11-5 4-methoxy-benzaldehyde 
• 68-11-1 mercaptoacetic acid 

Relevant articles and documents

Synthesis and biological evaluation of a class of 5-benzylidene-2-phenyl- thiazolinones as potent 5-lipoxygenase inhibitors

A class of 5-lipoxygenase (5-LO) inhibitors characterized by a central 5-benzylidene-2-phenyl-thiazolinone scaffold was synthesized as a new series of molecular modifications and extensions of a previously reported series. Compounds were tested in a cell-based and a cell-free assay and furthermore evaluated for their influence on cell viability. The presented substituted thiazolinone scaffold turned out to be essential for both the 5-LO inhibitory activity and the non-cytotoxic profile. With (Z)-5-(4-methoxybenzylidene)-2- (naphthalen-2-yl)-5H-thiazol-4-one (2k, ST1237), a potent, direct, non-cytotoxic 5-LO inhibitor with IC50 of 0.08 μM and 0.12 μM (cell-free assay and intact cells), we present a promising lead optimization and development for further investigations as novel anti-inflammatory drug.