1381841-42-4

Basic information

• Product Name: C₁₉H₂₀ClN₃
• CAS NO: 1381841-42-4
• Molecular Weight: 325.841
• Mol File: 1381841-42-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₉H₂₀ClN₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₂₀ClN₃(1381841-42-4)
• EPA Substance Registry System: C₁₉H₂₀ClN₃(1381841-42-4)

Safety Data

• Hazardous Substances Data: 1381841-42-4(Hazardous Substances Data)

Upstream product

• 953071-73-3 tert-butyl 4-(1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate 
• 38385-95-4 2-(4-piperidinyl)-1H-benzimidazole 
• 95-54-5 1,2-diamino-benzene 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 5729-18-0 N-(p-Chlorophenylmethyl)-2-amino aniline 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 498-94-2 isonipecotic acid 

Relevant articles and documents

Discovery of Novel 2-(piperidin-4-yl)-1H-benzo[d]imidazole Derivatives as Potential Anti-Inflammatory Agents

A novel 2-(piperidin-4-yl)-1H-benzo[d]imidazole derivative 5 with good anti-inflammatory activity was identified from our in-house library. Based on hit compound 5, two series of 2-(piperidin-4-yl)-1H-benzo[d]imidazole derivative 6a-g and 7a-h were designed and synthesized as novel anti-inflammatory agents. Most of synthesized compounds exhibited good inhibitory activity on NO and TNF-α production in LPS-stimulated RAW 264.7 macrophages, in which the compound 6e showed most potent inhibitory activity on NO (IC50 = 0.86 μm) and TNF-α (IC50 = 1.87 μm) production. Further evaluation revealed that compound 6e displayed more potent in vivo anti-inflammatory activity than ibuprofen did on xylene-induced ear oedema in mice. Additionally, Western blot analysis revealed that compound 6e could restore phosphorylation level of IκBα and protein expression of p65 NF-κB in LPS-stimulated RAW 264.7 macrophages.