1381984-87-7Relevant articles and documents
Benzylation of nitroalkanes using copper-catalyzed thermal redox catalysis: Toward the facile C-alkylation of nitroalkanes
Gildner, Peter G.,Gietter, Amber A. S.,Cui, Di,Watson, Donald A.
supporting information; experimental part, p. 9942 - 9945 (2012/08/07)
The C-alkylation of nitroalkanes under mild conditions has been a significant challenge in organic synthesis for more than a century. Herein we report a simple Cu(I) catalyst, generated in situ, that is highly effective for C-benzylation of nitroalkanes using abundant benzyl bromides and related heteroaromatic compounds. This process, which we believe proceeds via a thermal redox mechanism, allows access to a variety of complex nitroalkanes under mild reaction conditions and represents the first step toward the development of a general catalytic system for the alkylation of nitroalkanes.
