1381986-31-7

Basic information

• Product Name: (R)-1-(4-methoxyphenyl)-2-tosyl-1,2,3,4-tetrahydroisoquinoline
• Synonyms: (R)-1-(4-methoxyphenyl)-2-tosyl-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 1381986-31-7
• Molecular Weight: 393.507
• Mol File: 1381986-31-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-1-(4-methoxyphenyl)-2-tosyl-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(4-methoxyphenyl)-2-tosyl-1,2,3,4-tetrahydroisoquinoline(1381986-31-7)
• EPA Substance Registry System: (R)-1-(4-methoxyphenyl)-2-tosyl-1,2,3,4-tetrahydroisoquinoline(1381986-31-7)

Safety Data

• Hazardous Substances Data: 1381986-31-7(Hazardous Substances Data)

Upstream product

• 59224-73-6 1-(4'-methoxylphenyl)-3,4-dihydroisoquinoline 
• 98-59-9 p-toluenesulfonyl chloride 

Relevant articles and documents

Enantioselective synthesis of 1-aryl-tetrahydroisoquinolines through iridium catalyzed asymmetric hydrogenation

Asymmetric hydrogenation of 1-aryl-3,4-dihydroisoquinolines using the [IrCODCl]2/(R)-3,5-diMe-Synphos catalyst is reported. Under mild reaction conditions, this atom-economical process provides easy access to a variety of enantioenriched 1-aryl-1,2,3,4-tetrahydroisoquinoline derivatives, which are important pharmacophores found in several pharmaceutical drug candidates, in high yields and enantiomeric excesses up to 99% after a single crystallization.