138199-51-6 Usage
Description
(RS)-(TETRAZOL-5-YL)GLYCINE, also known as Tetrazolyl glycine, is an NMDA receptor agonist with potent neurochemical and neurophysiological effects. It demonstrates approximately 20 times more activity than N-methyl-D-aspartate (NMDA), a well-known agonist for the NMDA receptor. Tetrazolyl glycine is characterized by its ability to bind to rat brain membranes with high affinity and induce depolarization in rat cortical slices. Its interactions with the NMDA receptor have been associated with various neurophysiological and neuropathological processes.
Uses
Used in Pharmaceutical Industry:
(RS)-(TETRAZOL-5-YL)GLYCINE is used as a research compound for studying the role of NMDA receptors in various neurological and neurodegenerative disorders. Its potent agonist activity allows researchers to investigate the underlying mechanisms of these conditions and develop potential therapeutic strategies.
Used in Neurochemical Research:
(RS)-(TETRAZOL-5-YL)GLYCINE is used as a neurochemical tool to explore the function and regulation of NMDA receptors in the central nervous system. Its ability to induce depolarization and modulate the activity of GABAergic and cholinergic neurons makes it a valuable compound for understanding the complex interactions between different neurotransmitter systems.
Used in Neurophysiological Studies:
(RS)-(TETRAZOL-5-YL)GLYCINE is used as a pharmacological agent to investigate the effects of NMDA receptor activation on neuronal excitability and synaptic plasticity. Its ability to induce excitotoxic lesions and seizures in neonatal rats provides insights into the role of NMDA receptors in the development of neurodegenerative diseases and the potential for therapeutic intervention.
Used in Excitotoxicity Research:
(RS)-(TETRAZOL-5-YL)GLYCINE is used as a model compound to study the mechanisms of excitotoxicity-induced neuronal injury. Its ability to increase COX-2 expression in striatal neurons and the vasculature near the striatal injection site in a mouse model of excitotoxicity provides valuable information on the cellular and molecular processes involved in this type of injury.
Check Digit Verification of cas no
The CAS Registry Mumber 138199-51-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,8,1,9 and 9 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 138199-51:
(8*1)+(7*3)+(6*8)+(5*1)+(4*9)+(3*9)+(2*5)+(1*1)=156
156 % 10 = 6
So 138199-51-6 is a valid CAS Registry Number.
InChI:InChI=1/C3H5N5O2/c4-1(3(9)10)2-5-7-8-6-2/h1H,4H2,(H,9,10)(H,5,6,7,8)
