138222-93-2

Basic information

• Product Name: Piperidine, 1-[(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)methyl]-
• CAS NO: 138222-93-2
• Molecular Formula: C18H24N2
• Molecular Weight: 268.402
• Mol File: 138222-93-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Piperidine, 1-[(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidine, 1-[(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)methyl]-(138222-93-2)
• EPA Substance Registry System: Piperidine, 1-[(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)methyl]-(138222-93-2)

Safety Data

• Hazardous Substances Data: 138222-93-2(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 50-00-0 formaldehyd 
• 83-24-9 2,5-dimethyl-1-phenyl-1H-pyrrole 
• 62-53-3 aniline 

Relevant articles and documents

Study of the Mannich reaction: β-amino-methylation of N-aryl and N-azaheteroaryl-substituted 2,5-dimethylpyrroles, compounds with potential biological activity

Owing to the increasing need of drugs for the treatment of a variety of fungal and bacterial opportunistic infections, a study has been started with the aim of synthesizing structures amenable to a number of easy-to-perform structural modifications in order to meet the requirement of bypassing resistance phenomena. This paper reports on the synthesis of several N-(α-azaheteroaryl)-substituted 2,5-dimethyl-pyrroles bearing in one β-position (or in both β-positions) aminomethyl groups, introduced via a Mannich reaction. Electronic and steric effects by the N-(azaheteroaryl) substituents and the 2- and 5-methyl groups on the course of the Mannich reaction are discussed along with the results of in vitro tests against many Candida species, some bacteria, and several pathogenic plant fungi.

Research on antibacterial and antifungal agents

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