1382321-60-9

Basic information

• Product Name: 2-{[4-(4-methoxyphenyl)piperidin-1-yl]methyl}benzofuran-7-carboxamide
• CAS NO: 1382321-60-9
• Molecular Weight: 364.444
• Mol File: 1382321-60-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-{[4-(4-methoxyphenyl)piperidin-1-yl]methyl}benzofuran-7-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{[4-(4-methoxyphenyl)piperidin-1-yl]methyl}benzofuran-7-carboxamide(1382321-60-9)
• EPA Substance Registry System: 2-{[4-(4-methoxyphenyl)piperidin-1-yl]methyl}benzofuran-7-carboxamide(1382321-60-9)

Safety Data

• Hazardous Substances Data: 1382321-60-9(Hazardous Substances Data)

Upstream product

• 1382321-15-4 2-methylbenzofuran-7-carboxamide 
• 1382321-12-1 3-(2-bromoallyl)-2-hydroxybenzamide 
• 1241182-92-2 2-[(2-bromoallyl)oxy]benzamide 
• 67259-62-5 4-(4-methoxyphenyl)piperidine 
• 1382321-18-7 2-bromomethylbenzofuran-7-carboxamide 

Relevant articles and documents

Studies on benzofuran-7-carboxamides as poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors

Benzofuran-7-carboxamide was identified as a novel scaffold of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor. A series of compounds with various 2-substituents including (tertiary amino)methyl moieties substituted with aryl ring and aryl groups containing tertiary amines, were synthesized and biologically evaluated to elucidate the structure-activity relationships and optimize the potency. 2-[4-(Pyrrolidin-1-ylmethyl)phenyl]-benzofuran-7- carboxamide (42) was the most potent as an IC50 value of 40 nM among those.