1382997-49-0

Basic information

• Product Name: (1S,5S,6R,7S)-6-(4-fluorophenyl)-1-hydroxy-7-nitrobicyclo[3.2.1]octan-8-one
• Synonyms: (1S,5S,6R,7S)-6-(4-fluorophenyl)-1-hydroxy-7-nitrobicyclo[3.2.1]octan-8-one
• CAS NO: 1382997-49-0
• Molecular Weight: 279.268
• Mol File: 1382997-49-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (1S,5S,6R,7S)-6-(4-fluorophenyl)-1-hydroxy-7-nitrobicyclo[3.2.1]octan-8-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,5S,6R,7S)-6-(4-fluorophenyl)-1-hydroxy-7-nitrobicyclo[3.2.1]octan-8-one(1382997-49-0)
• EPA Substance Registry System: (1S,5S,6R,7S)-6-(4-fluorophenyl)-1-hydroxy-7-nitrobicyclo[3.2.1]octan-8-one(1382997-49-0)

Safety Data

• Hazardous Substances Data: 1382997-49-0(Hazardous Substances Data)

Upstream product

• 5153-69-5 4-fluoro-β-nitrostyrene 
• 765-87-7 cyclohexane-1,2-dione 

Relevant articles and documents

Asymmetric domino Michael-Henry reaction of 1,2-diones with nitroolefins catalyzed by a chiral bisoxazolidine-Ni(acac)2 complex

The asymmetric domino Michael-Henry reaction of 1,2-cyclohexadione with nitroolefins catalyzed by chiral ligand bisoxazolidine 1 and Ni(acac) 2 has been developed. This process provided highly functionalized chiral bicycle[3,2,1] octane derivatives with the generation of four new stereogenic centers in high yields (76-99%), and with excellent enantioselectivities (up to 99%) and good diastereoselectivities (up to 9:1) under mild reaction conditions. The procedure presented is simple and makes this method suitable for practical use.