138334-84-6

Basic information

• Product Name: 2-[2-(2-Methoxy-6-nitro-phenyl)-1-(4-methoxy-phenyl)-ethyl]-malonic acid dimethyl ester
• Synonyms: 2-[2-(2-Methoxy-6-nitro-phenyl)-1-(4-methoxy-phenyl)-ethyl]-malonic acid dimethyl ester
• CAS NO: 138334-84-6
• Molecular Weight: 417.416
• Mol File: 138334-84-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-[2-(2-Methoxy-6-nitro-phenyl)-1-(4-methoxy-phenyl)-ethyl]-malonic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-(2-Methoxy-6-nitro-phenyl)-1-(4-methoxy-phenyl)-ethyl]-malonic acid dimethyl ester(138334-84-6)
• EPA Substance Registry System: 2-[2-(2-Methoxy-6-nitro-phenyl)-1-(4-methoxy-phenyl)-ethyl]-malonic acid dimethyl ester(138334-84-6)

Safety Data

• Hazardous Substances Data: 138334-84-6(Hazardous Substances Data)

Upstream product

• 4837-88-1 6-methoxy-2-nitrotoluene 
• 7443-25-6 dimethyl 2-(4-methoxybenzylidene)malonate 

Downstream Products

• 138335-40-7 (3R,4S)-1-(2-Dimethylamino-ethyl)-6-methoxy-4-(4-methoxy-phenyl)-3-methyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-one 
• 138573-52-1 (3S,4R)-6-Methoxy-4-(4-methoxy-phenyl)-3-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-3-carboxylic acid methyl ester 
• 138335-19-0 6-Methoxy-4-(4-methoxy-phenyl)-3-methyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-one 
• 138573-52-1 (3S,4S)-6-Methoxy-4-(4-methoxy-phenyl)-3-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-3-carboxylic acid methyl ester 
• 138335-19-0 (3R,4R)-6-Methoxy-4-(4-methoxy-phenyl)-3-methyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-one 
• 138334-47-1 Acetic acid (3S,4R)-1-(2-dimethylamino-ethyl)-6-methoxy-4-(4-methoxy-phenyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl ester 
• 138335-40-7 (3S,4S)-1-(2-Dimethylamino-ethyl)-6-methoxy-4-(4-methoxy-phenyl)-3-methyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-one 
• 138335-01-0 (3R,4S)-3-Hydroxy-6-methoxy-4-(4-methoxy-phenyl)-1,3,4,5-tetrahydro-benzo[b]azepin-2-one 
• 138335-01-0 (3S,4S)-3-Hydroxy-6-methoxy-4-(4-methoxy-phenyl)-1,3,4,5-tetrahydro-benzo[b]azepin-2-one 
• 138573-38-3 2-[2-(2-Amino-6-methoxy-phenyl)-1-(4-methoxy-phenyl)-ethyl]-2-methyl-malonic acid dimethyl ester 
• 138573-26-9 2-[2-(2-Methoxy-6-nitro-phenyl)-1-(4-methoxy-phenyl)-ethyl]-2-methyl-malonic acid dimethyl ester 

Relevant articles and documents

Benzazepinone calcium channel blockers. 2. Structure-activity and drug metabolism studies leading to potent antihypertensive agents. Comparison with benzothiazepinones

As part of a program to discover potent antihypertensive analogues of diltiazem (3a), we prepared 1-benzazepin-2-ones (4). Benzazepinones competitively displace radiolabeled diltiazem, and show the same absolute stereochemical preferences at the calcium channel receptor protein. Derivatives of 4 containing a trifluoromethyl substituent in the fused aromatic ring show potent and long-acting antihypertensive activity. Studies of the metabolism of 4 lead to the metabolically stable antihypertensive calcium channel blockers 5a and 5c. Benzazepinone 5a is a longer acting and more potent antihypertensive agent than the second generation diltiazem analogue TA-3090 (3e).