1383531-68-7

Basic information

• Product Name: lapatinib monohydrochloride
• Synonyms: lapatinib monohydrochloride
• CAS NO: 1383531-68-7
• Molecular Weight: 617.528
• Mol File: 1383531-68-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: lapatinib monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: lapatinib monohydrochloride(1383531-68-7)
• EPA Substance Registry System: lapatinib monohydrochloride(1383531-68-7)

Safety Data

• Hazardous Substances Data: 1383531-68-7(Hazardous Substances Data)

Upstream product

• 16064-08-7 6-iodo-4-hydroxyquinazoline 
• 1383531-71-2 2-(methylsulphonyl)-N-({5-[4-(tetrahydro-2H-pyran-2-yloxy)quinazolin-6-yl]furan-2-yl}methyl)ethanamine 
• 1383531-70-1 5-[4-(tetrahydro-2H-pyran-2-yloxy)quinazolin-6-yl]furan-2-carbaldheyde 
• 1334953-74-0 6-[5-({[2-(methylsulphonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-ol 
• 1383531-69-8 6-iodo-4-(tetrahydro-2H-pyran-2-yloxy)quinazoline 
• 388082-78-8 lapatinib ditosylate 
• 231277-92-2 lapatanib 

Downstream Products

• 388082-78-8 lapatinib ditosylate 

Relevant articles and documents

CO-CRYSTALS OF LAPATINIB MONOACID SALTS

The present invention refers to co-crystals of monoacid salts of the pharmaceutical active ingredient named Lapatinib and to processes for the preparation thereof and medical uses.

METHODS FOR THE PREPARATION OF LAPATINIB AND THE SALTS THEREOF

Methods for the synthesis of the pharmaceutically active ingredient Lapatinib and the salts thereof are provided. In particular, such methods utilize intermediates in which the hydroxyl function is protected by a tetrahydropyranyl group providing greater solubility of the intermediates in common organic solvents.