1383536-26-2

Basic information

• Product Name: 3,4-dibromo-5-(3-bromo-2-(2-(2,3-dibromo-4,5-dihydroxybenzyl)-4,5-dihydroxybenzyl)-4,5-dihydroxybenzyl)benzene-1,2-diol
• Synonyms: 3,4-dibromo-5-(3-bromo-2-(2-(2,3-dibromo-4,5-dihydroxybenzyl)-4,5-dihydroxybenzyl)-4,5-dihydroxybenzyl)benzene-1,2-diol
• CAS NO: 1383536-26-2
• Molecular Weight: 870.963
• Mol File: 1383536-26-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3,4-dibromo-5-(3-bromo-2-(2-(2,3-dibromo-4,5-dihydroxybenzyl)-4,5-dihydroxybenzyl)-4,5-dihydroxybenzyl)benzene-1,2-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-dibromo-5-(3-bromo-2-(2-(2,3-dibromo-4,5-dihydroxybenzyl)-4,5-dihydroxybenzyl)-4,5-dihydroxybenzyl)benzene-1,2-diol(1383536-26-2)
• EPA Substance Registry System: 3,4-dibromo-5-(3-bromo-2-(2-(2,3-dibromo-4,5-dihydroxybenzyl)-4,5-dihydroxybenzyl)-4,5-dihydroxybenzyl)benzene-1,2-diol(1383536-26-2)

Safety Data

• Hazardous Substances Data: 1383536-26-2(Hazardous Substances Data)

Upstream product

• 6948-30-7 5-bromoveratralaldehyde 
• 20731-48-0 3-bromo-4,5-dimethoxybenzoic acid 
• 1383536-25-1 2,3-dibromo-1-(2-(3-bromo-2-(2,3-dibromo-4,5-dimethoxybenzyl)-4,5-dimethoxybenzyl)-4,5-dimethoxybenzyl)-4,5-dimethoxybenzene 
• 1383535-99-6 1-bromo-5-(3,4-dimethoxybenzyl)-2,3-dimethoxybenzene 
• 1383535-97-4 (3-bromo-4,5-dimethoxyphenyl)(3,4-dimethoxyphenyl)methanone 

Relevant articles and documents

Design, synthesis, and biological evaluation of bromophenol derivatives as protein tyrosine phosphatase 1B inhibitors

3-Bromo-4,5-bis(2,3-dibromo-4,5-dihydroxybenzyl)-1,2-benzenediol (BDB) is a bromophenol purified from the marine red alga Rhodomela confervoides and exhibits potent protein tyrosine phosphatase 1B (PTP1B) inhibition (IC 50 = 1.7 μmol/L). In an effort to improve the PTP1B inhibitory activity, a series of derivatives were designed, synthesized, and evaluated in vitro. The preliminary structure-activity relationship indicated that the tricyclic scaffold and multi-bromine atoms (four to five) attached to the aryl rings are important for PTP1B inhibition. Among these, compound 26 exhibited remarkable inhibitory activity against PTP1B with an IC50 of 0.89 μmol/L, which was approximately two-fold more potent than the initial lead compound BDB.