138354-50-4

Basic information

• Product Name: 1H-Indole-2-carboxamide, N-(3,3-diphenylpropyl)-
• CAS NO: 138354-50-4
• Molecular Formula: C24H22N2O
• Molecular Weight: 354.451
• Mol File: 138354-50-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Indole-2-carboxamide, N-(3,3-diphenylpropyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-2-carboxamide, N-(3,3-diphenylpropyl)-(138354-50-4)
• EPA Substance Registry System: 1H-Indole-2-carboxamide, N-(3,3-diphenylpropyl)-(138354-50-4)

Safety Data

• Hazardous Substances Data: 138354-50-4(Hazardous Substances Data)

Upstream product

• 1477-50-5 Indole-2-carboxylic acid 
• 5586-73-2 3-diphenylpropyl amine 

Relevant articles and documents

Hybrid Cholecystokinin-A Antagonists Based on Molecular Modelling of Lorglumide and L-364,718

A series of novel nonpeptide cholecystokinin-A (CCK-A) antagonists have been synthesized.Designed on the basis of the structural homology between lorgumide and L-364,718, as investigated with molecular modeling, these compounds constitute a link between the N-acylglutamic acid and 3-amino-5-phenyl-1,4-benzodiazepin-2-one derived antagonists.The prepared compounds were tested in vitro as antagonists of the binding of -(+/-)-L-364,718 and -CCK-8(S) to rat pancreas and guinea pig brain membranes, respectively.All compounds proved to be selective for the(peripheral) CCK-A receptor, the most potent analogue, 6, having a Ki value of 90 nM.The structure-activity profile of the series of hybrid compounds relates closest to that of the N-acylglutamic acid derived antagonists.