1383569-21-8Relevant articles and documents
Catalytic Enantio- And Diastereoselective Cyclopropanation of 2-Azadienes for the Synthesis of Aminocyclopropanes Bearing Quaternary Carbon Stereogenic Centers
Shao, Xinxin,Malcolmson, Steven J.
supporting information, p. 7380 - 7385 (2019/10/02)
We report the catalytic enantio- and diastereoselective preparation of aminocyclopropanes by the cyclopropanation of terminal and (Z)-internal 2-azadienes with donor/acceptor carbenes derived from α-diazoesters. The resulting cyclopropanes bear quaternary carbon stereogenic centers vicinal to the amino-substituted carbon and are formed as a single diastereomer in up to 99:1 er and 97% yield with 0.5 mol % of Rh2(DOSP)4 and only 1.5 equiv of the diazo reagent. Transformations with internal azadienes afford cyclopropanes with three contiguous stereogenic centers.
Radioiodinated dechloro-4-iodofenofibrate: A hydrophobic model drug for molecular imaging studies
Breyer, Sandra,Semmler, Angelika,Miller, Tobias,Hill, Alexandra,Geissler, Simon,Haberkorn, Uwe,Mier, Walter
, p. 78 - 83 (2012/08/27)
Radiolabeling is a valuable option for tracking drug molecules in biodistribution experiments. In the development of innovative drug delivery systems the influence of the pharmaceutical formulation on the drugs' pharmacokinetics has to be investigated. Th
