1383718-45-3

Basic information

• Product Name: N-(3-chlorophenyl)-5,6,7,8-tetrahydroquinazolin-2-amine
• Synonyms: N-(3-chlorophenyl)-5,6,7,8-tetrahydroquinazolin-2-amine
• CAS NO: 1383718-45-3
• Molecular Weight: 259.738
• Mol File: 1383718-45-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(3-chlorophenyl)-5,6,7,8-tetrahydroquinazolin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-chlorophenyl)-5,6,7,8-tetrahydroquinazolin-2-amine(1383718-45-3)
• EPA Substance Registry System: N-(3-chlorophenyl)-5,6,7,8-tetrahydroquinazolin-2-amine(1383718-45-3)

Safety Data

• Hazardous Substances Data: 1383718-45-3(Hazardous Substances Data)

Upstream product

• 108-94-1 cyclohexanone 
• 6135-19-9 2-((dimethylamino)methylene)cyclohexanone 
• 38647-81-3 (3-Chlorophenyl)guanidine nitrate 

Relevant articles and documents

Discovery, synthesis, and structure-activity relationships of 2-aminoquinazoline derivatives as a novel class of metabotropic glutamate receptor 5 negative allosteric modulators

A virtual screening approach using various in silico methodologies led to the discovery of 2-(m-tolylamino)-7,8-dihydroquinazolin-5(6H)-one (1) as a moderately active negative allosteric modulator (NAM) of the metabotropic glutamate receptor subtype 5 (mGluR5) showing high selectivity against the subtype mGluR1. Modifications of the parent compound by rational design yielded a series of highly potent derivatives which will serve as valuable starting points for further hit-to-lead optimization efforts toward a suitable drug candidate for the treatment of l-DOPA induced dyskinesia.