1384110-75-1

Basic information

• Product Name: C₂₃H₂₅FN₆O₂
• Synonyms: C₂₃H₂₅FN₆O₂
• CAS NO: 1384110-75-1
• Molecular Weight: 436.489
• Mol File: 1384110-75-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₅FN₆O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₅FN₆O₂(1384110-75-1)
• EPA Substance Registry System: C₂₃H₂₅FN₆O₂(1384110-75-1)

Safety Data

• Hazardous Substances Data: 1384110-75-1(Hazardous Substances Data)

Upstream product

• 22246-13-5 6-amino-3,4-dihydro-1H-quinolin-2-one 
• 1384110-71-7 C₁₂H₁₁ClN₄O₂ 
• 55513-19-4 1-(3-fluoro-benzyl)-piperazine 
• 1384110-70-6 C₁₀H₁₀N₄O 

Relevant articles and documents

Synthesis and positive inotropic evaluation of N-(1-oxo-1,2,4,5-tetrahydro- [1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides bearing piperazine and 1,4-diazepane moieties

Two series of N-(1-oxo-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinolin-7- yl)acetamides bearing piperazine and 1,4-diazepane moieties were synthesized and screened for their positive inotropic activity by measuring left atrium stroke volume on isolated rabbit heart preparations. Most of the derivatives exhibited better in vitro positive inotropic activity than the existing drug, milrinone, among which 2-(4-(4-chlorobenzyl)-1,4-diazepan-1-yl)-N-(1-oxo-1,2,4,5- tetrahydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamide 6c proved to be the most potent with 15.48 ± 0.27% increased stroke volume (milrinone: 2.46 ± 0.07%) at a concentration of 3 × 10-5 M. The chronotropic effects of the compounds that exhibited inotropic effects were also evaluated.