1384282-49-8

Basic information

• Product Name: C₃₈H₃₀F₁₂N₄O₈
• CAS NO: 1384282-49-8
• Molecular Weight: 898.659
• Mol File: 1384282-49-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₈H₃₀F₁₂N₄O₈(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₈H₃₀F₁₂N₄O₈(1384282-49-8)
• EPA Substance Registry System: C₃₈H₃₀F₁₂N₄O₈(1384282-49-8)

Safety Data

• Hazardous Substances Data: 1384282-49-8(Hazardous Substances Data)

Upstream product

• 135586-17-3 3-(benzyloxy)-2-bromo-4-methoxybenzoic acid 
• 1233979-42-4 6,6'-dihydroxy-5,5'-dimethoxy-N,N'-dimethylbiphenyl-2,2'-dicarboxamide 
• 790-75-0 N-(3,5-bis-trifluoromethyl-phenyl)-2-chloro-acetamide 
• 1233979-41-3 6,6'-bis(benzyloxy)-5,5'-dimethoxy-N,N'-dimethylbiphenyl-2,2'-dicarboxamide 
• 1233979-39-9 3-(benzyloxy)-2-bromo-4-methoxy-N-methylbenzamide 

Relevant articles and documents

Facile synthesis and biological evaluation of novel symmetrical biphenyls as Antitumor Agents

As a continuation to our previous work in developing anticancer agents, eighteen symmetrical biphenyl derivatives structurally related to taspine were synthesized and evaluated in vitro and in vivo. All the compounds were prepared with varied substitutions in the phenyl ring of aniline moiety. The cytotoxicity and anticancer activity of biphenyls was evaluated against various human tumor and normal cell line. Antiproliferative assays indicated that some of them exhibited potent anticancer activity. The potent antiproliferative activity of these compounds against ECV304 suggested that these biphenyls could be served as antiangiogenic agents. The highly active compound (2) also exhibited potent growth inhibition against cancer cell lines in vivo. Our findings demonstrated that these symmetrical biphenyl derivatives would be a promising candidate as novel anticancer agents.